SCHEMBL8635876

SCHEMBL8635876

O=C1CCCc2cc(-c3ccccc3F)ccc21

nearest known ligand 0.56

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
HSD17B1 P14061 4/20 0.56
MAOA P21397 7/20 0.56
MAOB P27338 7/20 0.56
CYP2A6 P11509 1/20 0.56
HRH3 Q9Y5N1 1/20 0.54
PTPRC P08575 1/20 0.53
PTPN1 P18031 1/20 0.53
PARP1 P09874 1/20 0.51
PARP2 Q9UGN5 1/20 0.51
PRKCI P41743 1/20 0.50
GRM5 P41594 1/20 0.50
PGR P06401 1/20 0.45
BAZ2B Q9UIF8 1/20 0.42
CYP1A2 P05177 1/20 0.42
CYP11B1 P15538 1/20 0.42
CYP11B2 P19099 1/20 0.42
DHODH Q02127 1/20 0.42
MAPK14 Q16539 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8072264 0.97 HRH3 (0.54) HSD17B1MAOAMAOBCYP2A6HRH3
SCHEMBL8633556 0.90 HSD17B1 (0.60) HSD17B1MAOAMAOBCYP2A6HRH3
SCHEMBL7504001 0.88 MAOA (0.56) HSD17B1MAOAMAOBCYP2A6HRH3
SCHEMBL7507475 0.84 HSD17B1 (0.56) HSD17B1MAOAMAOBCYP2A6HRH3
SCHEMBL7509673 0.84 HSD17B1 (0.56) HSD17B1MAOAMAOBCYP2A6PRKCI
SCHEMBL8635759 0.84 PTPRC (0.53) HSD17B1MAOAMAOBCYP2A6HRH3
SCHEMBL8632736 0.82 PARP1 (0.50) HRH3PTPRCPTPN1PARP1PARP2
SCHEMBL4416659 0.81 HSD17B1 (0.64) HSD17B1MAOAMAOBCYP2A6HRH3
SCHEMBL7584101 0.80 HSD17B1 (0.73) HSD17B1MAOAMAOBCYP2A6HRH3
SCHEMBL7499572 0.79 MAOA (0.53) HSD17B1MAOAMAOBCYP2A6HRH3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0601191-B1 NOVEL TETRACYCLIC COMPOUND KYOWA HAKKO KOGYO KK (JP) 1998-07-22 EP disclosed
US-5371225-A Immunosuppressants KYOWA HAKKO KOGYO CO., LTD. (JP) 1994-12-06 US disclosed
EP-0601191-A1 NOVEL TETRACYCLIC COMPOUND KYOWA HAKKO KOGYO KABUSHIKI KAISHA (JP) 1994-06-15 EP disclosed