Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 5/20 | 0.49 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.37 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
| ▸ | F10 | P00742 | 3/20 | 0.34 |
| ▸ | CA1 | P00915 | 2/20 | 0.34 |
| ▸ | CA2 | P00918 | 2/20 | 0.34 |
| ▸ | CA4 | P22748 | 2/20 | 0.34 |
| ▸ | CA9 | Q16790 | 2/20 | 0.34 |
| ▸ | GRN | P28799 | 1/20 | 0.34 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.34 |
| ▸ | F2 | P00734 | 2/20 | 0.34 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.34 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.34 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8630965 | 0.91 | PTGS2 (0.47) | PTGS2PTGS1TRPV1F10F2 | |
| SCHEMBL8631028 | 0.91 | PTGS2 (0.41) | PTGS2PTGS1F10F2PRSS1 | |
| SCHEMBL8629349 | 0.88 | PTGS2 (0.48) | PTGS2PTGS1F10CA1CA2 | |
| SCHEMBL7779827 | 0.87 | PTGS2 (0.60) | PTGS2PTGS1CA1CA2CA4 | |
| SCHEMBL8631591 | 0.85 | PTGS2 (0.41) | PTGS2F10CA1CA2CA4 | |
| SCHEMBL8631053 | 0.85 | PTGS2 (0.44) | PTGS2PTGS1F10F2P2RX3 | |
| SCHEMBL8632288 | 0.84 | PTGS2 (0.67) | PTGS2PTGS1TRPV1F10F2 | |
| SCHEMBL8631787 | 0.83 | PTGS2 (0.40) | PTGS2F10CA1CA2CA4 | |
| SCHEMBL8629933 | 0.83 | PTGS2 (0.46) | PTGS2PTGS1F10F2PRSS1 | |
| SCHEMBL8633616 | 0.82 | PTGS2 (0.39) | PTGS2F10CA1CA2CA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5756530-A | NON-STEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G. D. SEARLE & CO. (US) | 1998-05-26 | — | — | US | disclosed |