Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 4/20 | 0.47 |
| ▸ | PTGES2 | Q9H7Z7 | 2/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | F10 | P00742 | 3/20 | 0.35 |
| ▸ | F2 | P00734 | 2/20 | 0.35 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.35 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.35 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8631861 | 0.92 | HTR7 (0.38) | PTGS2F10F2PRSS1PRSS2 | |
| SCHEMBL8632828 | 0.91 | PTGS2 (0.49) | PTGS2PTGES2F10F2PRSS1 | |
| SCHEMBL7779760 | 0.87 | PTGS2 (0.58) | PTGS2PTGS1 | |
| SCHEMBL8628738 | 0.87 | PTGS2 (0.48) | PTGS2F10F2PRSS1PRSS2 | |
| SCHEMBL8632288 | 0.84 | PTGS2 (0.67) | PTGS2PTGES2F10F2PRSS1 | |
| SCHEMBL8630565 | 0.84 | PTGS2 (0.40) | PTGS2PTGES2ADORA2AF10KDM4E | |
| SCHEMBL8629984 | 0.84 | PTGS2 (0.44) | PTGS2F10F2PRSS1PRSS2 | |
| SCHEMBL8627776 | 0.83 | PTGS2 (0.38) | PTGS2PTGES2ADORA2AKDM4EHPGD | |
| SCHEMBL8631028 | 0.83 | PTGS2 (0.41) | PTGS2F10F2PRSS1PRSS2 | |
| SCHEMBL8631053 | 0.83 | PTGS2 (0.44) | PTGS2F10F2PTGS1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5756530-A | NON-STEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G. D. SEARLE & CO. (US) | 1998-05-26 | — | — | US | disclosed |