SCHEMBL8633116

SCHEMBL8633116

NS(=O)(=O)c1ccc(-c2nnc(S)o2)cc1

nearest known ligand 0.68

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
CA2 P00918 16/20 0.68
CA1 P00915 15/20 0.68
MAOA P21397 5/20 0.68
MAOB P27338 5/20 0.68

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16157232 0.84 GSK3B (0.56) CA2CA1MAOAMAOB
SCHEMBL28366821 0.83 CA2 (0.73) CA2CA1MAOAMAOB
SCHEMBL28373035 0.79 CA2 (1.00) CA2CA1MAOAMAOB
SCHEMBL28370993 0.79 CA2 (1.00) CA2CA1MAOAMAOB
SCHEMBL7724942 0.76 RAB9A (0.72)
SCHEMBL28367154 0.76 CA2 (0.78) CA2CA1MAOAMAOB
SCHEMBL28884814 0.76 CA2 (1.00) CA2CA1MAOAMAOB
SCHEMBL16197318 0.75 RXFP1 (0.64)
SCHEMBL28372518 0.74 CA2 (1.00) CA2CA1MAOAMAOB
SCHEMBL16197255 0.74 RXFP1 (0.67)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-RE35754-E FOR TREATING BACTERIAL INFECTIONS HOECHST AKTIENGESELLSCHAFT (DE) 1998-03-24 US disclosed
US-5710146-A ANTIBIOTICS FOR BACTERICIDES HOECHST AKTIENGESELLSCHAFT (DE) 1998-01-20 US disclosed
US-5089490-A Cephem derivatives HOECHST AKTIENGESELLSCHAFT (DE) 1992-02-18 US disclosed
US-4758556-A Cephem derivatives HOECHST AKTIENGESELLSCHAFT (DE) 1988-07-19 US disclosed
US-4278793-A ANTIBIOTICS, BACTERICIDES HOECHST AKTIENGESELLSCHAFT (DE) 1981-07-14 US disclosed