Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.34 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.34 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.34 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.34 |
| ▸ | DDR1 | Q08345 | 4/20 | 0.33 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.33 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2057487 | 0.81 | HSD17B10 (0.37) | MAPK1KDM4ELMNAHPGDHIF1A | |
| SCHEMBL8633774 | 0.81 | TET2 (0.36) | TSHRMAPK1KDM4ETET2MEP1B | |
| SCHEMBL2057737 | 0.80 | TRPA1 (0.36) | TSHRMAPK1LMNAHPGDHIF1A | |
| SCHEMBL8661123 | 0.79 | ALDH1A1 (0.35) | LMNAHPGDHIF1AHSD17B10ALDH1A1 | |
| SCHEMBL8664478 | 0.75 | MYC (0.41) | TSHRLMNAHPGDHIF1AHSD17B10 | |
| SCHEMBL10590409 | 0.72 | PARP1 (0.41) | TSHRKDM4ETET2MEP1BAKR1B1 | |
| SCHEMBL2687440 | 0.71 | HSD17B10 (0.37) | TSHRMAPK1KDM4ELMNAHPGD | |
| SCHEMBL16339268 | 0.71 | TSHR (0.47) | TSHRMAPK1KDM4EMEP1BL3MBTL1 | |
| SCHEMBL14991466 | 0.71 | PSEN1 (0.39) | TSHRMAPK1KDM4ETET2DDR1 | |
| SCHEMBL14991258 | 0.71 | PSEN1 (0.39) | TSHRMAPK1KDM4ETET2DDR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5705702-A | REACTING AN ARYL GRIGNARD REAGENT WITH THIONYL CHLORIDE, THEN WITH TRIORGANOSILYL SULFONATE OR TRIORGANOSILYLHALIDE | SHIN-ETSU CHEMICAL CO., LTD. (JP) | 1998-01-06 | — | — | US | disclosed |