Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | DAO | P14920 | 1/20 | 0.50 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.50 |
| ▸ | PARP1 | P09874 | 1/20 | 0.50 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.46 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.46 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.46 |
| ▸ | DHODH | Q02127 | 7/20 | 0.44 |
| ▸ | FLT3 | P36888 | 1/20 | 0.44 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.43 |
| ▸ | PIM1 | P11309 | 1/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | CDC25B | P30305 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10618201 | 0.74 | NPC1 (0.45) | KDM4EHSD17B10MAPTHPGDDAO | |
| SCHEMBL8633600 | 0.73 | KDM4E (0.60) | KDM4EHSD17B10MAPTHPGDNR4A1 | |
| SCHEMBL2490337 | 0.72 | KDM4E (0.63) | KDM4EMAPTHPGDPARP1DHODH | |
| SCHEMBL30749415 | 0.70 | PARP1 (0.73) | KDM4EHSD17B10MAPTHPGDPARP1 | |
| SCHEMBL30455376 | 0.70 | PARP1 (0.73) | KDM4EHSD17B10MAPTHPGDPARP1 | |
| SCHEMBL29364659 | 0.70 | KDM4E (0.59) | KDM4EHSD17B10MAPTHPGDDAO | |
| SCHEMBL31394 | 0.70 | KDM4E (0.59) | KDM4EHSD17B10MAPTHPGDDAO | |
| SCHEMBL2183473 | 0.70 | PARP1 (0.73) | KDM4EHSD17B10MAPTHPGDPARP1 | |
| SCHEMBL10592380 | 0.70 | FLT3 (0.71) | KDM4EHSD17B10MAPTHPGDDAO | |
| SCHEMBL27437769 | 0.70 | KDR (0.56) | KDM4EHSD17B10MAPTHPGDDAO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0601191-B1 | NOVEL TETRACYCLIC COMPOUND | KYOWA HAKKO KOGYO KK (JP) | 1998-07-22 | — | — | EP | disclosed |
| US-5371225-A | Immunosuppressants | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1994-12-06 | — | — | US | disclosed |
| EP-0601191-A1 | NOVEL TETRACYCLIC COMPOUND | KYOWA HAKKO KOGYO KABUSHIKI KAISHA (JP) | 1994-06-15 | — | — | EP | disclosed |