Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 2/20 | 0.56 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.56 |
| ▸ | MTNR1B | P49286 | 6/20 | 0.52 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8636057 | 0.91 | HTR1A (0.54) | HTR1ASLC6A4MTNR1BMEN1KMT2A | |
| SCHEMBL8636963 | 0.89 | HTR1A (0.61) | HTR1ASLC6A4MTNR1BMEN1KMT2A | |
| SCHEMBL8635640 | 0.86 | SLC6A4 (0.60) | HTR1ASLC6A4MTNR1BMEN1KMT2A | |
| SCHEMBL8638699 | 0.85 | HTR1A (0.56) | HTR1ASLC6A4MTNR1BMEN1KMT2A | |
| SCHEMBL8635354 | 0.84 | SLC6A4 (0.55) | HTR1ASLC6A4MTNR1BMEN1KMT2A | |
| SCHEMBL8635447 | 0.83 | MTNR1B (0.67) | HTR1ASLC6A4MTNR1BMTNR1AMEN1 | |
| SCHEMBL8637331 | 0.83 | MTNR1B (0.71) | HTR1ASLC6A4MTNR1BMTNR1AKDM4E | |
| SCHEMBL8633694 | 0.82 | SLC6A4 (0.55) | HTR1ASLC6A4MTNR1BMEN1KMT2A | |
| SCHEMBL8635236 | 0.81 | MTNR1B (0.56) | HTR1ASLC6A4MTNR1BSMN1; SMN2 | |
| SCHEMBL8637276 | 0.81 | SLC6A4 (0.54) | HTR1ASLC6A4MTNR1BMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0718286-B1 | 3-Alkoxybenzylpiperidine derivatives as melatonergic agents | BRISTOL MYERS SQUIBB CO (US) | 1998-07-29 | — | — | EP | claimed |
| EP-0718286-A1 | 3-Alkoxybenzylpiperidine derivatives as melatonergic agents | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-06-26 | — | — | EP | claimed |
| EP-0718286-B1 | 3-Alkoxybenzylpiperidine derivatives as melatonergic agents | BRISTOL MYERS SQUIBB CO (US) | 1998-07-29 | — | — | EP | disclosed |
| EP-0718286-A1 | 3-Alkoxybenzylpiperidine derivatives as melatonergic agents | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-06-26 | — | — | EP | disclosed |
| US-5530012-A | FOR SLEEP DISORDERS, DEPRESSION, GLAUCOMA, CANCER | BRISTOL-MYERS SQUIBB CO. (US) | 1996-06-25 | — | — | US | disclosed |