Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 4/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 4/20 | 0.32 |
| ▸ | EPAS1 | Q99814 | 4/20 | 0.32 |
| ▸ | MGAM | O43451 | 3/20 | 0.32 |
| ▸ | SI | P14410 | 3/20 | 0.32 |
| ▸ | MGAM2 | Q2M2H8 | 3/20 | 0.32 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.31 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | CASP1 | P29466 | 1/20 | 0.31 |
| ▸ | CASP7 | P55210 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.31 |
| ▸ | PLCG2 | P16885 | 1/20 | 0.31 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL615263 | 0.71 | PTGS2 (0.45) | MAPTNPC1RAB9AALDH1A1KDM4E | |
| SCHEMBL2431654 | 0.70 | CTSD (0.41) | MAPTNPC1RAB9AKDM4EGAA | |
| SCHEMBL5546004 | 0.68 | MAPT (0.44) | MAPTALDH1A1KDM4EGAAHIF1A | |
| SCHEMBL4174493 | 0.68 | MMP12 (0.51) | MAPTNPC1RAB9AALDH1A1KDM4E | |
| SCHEMBL10131895 | 0.67 | GAA (0.38) | ALDH1A1GAAHPGDHSD17B10 | |
| SCHEMBL8632438 | 0.67 | ESR2 (0.41) | MAPTALDH1A1KDM4EHIF1AEPAS1 | |
| SCHEMBL12035985 | 0.66 | MAPT (0.41) | MAPTALDH1A1KDM4EGAAHIF1A | |
| SCHEMBL8104414 | 0.66 | MAPT (0.41) | MAPTNPC1RAB9AALDH1A1KDM4E | |
| SCHEMBL20010406 | 0.65 | PTGS2 (0.37) | PDE3BPDE3A | |
| SCHEMBL19729111 | 0.65 | CYP2A6 (0.42) | ALDH1A1HPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5712281-A | Insecticidal substituted-2,4-diamino-5,6,7,8-tetrahydroquinazolines | FMC CORPORATION (US) | 1998-01-27 | — | — | US | disclosed |
| US-5536725-A | Insecticidal substituted-2,4-diamino-5,6,7,8-tetrahydroquinazolines | FMC CORPORATION (US) | 1996-07-16 | — | — | US | disclosed |