Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RECQL | P46063 | 2/20 | 0.55 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.52 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | HTR1A | P08908 | 1/20 | 0.48 |
| ▸ | DRD2 | P14416 | 1/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.47 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.47 |
| ▸ | KMO | O15229 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | NOS3 | P29474 | 1/20 | 0.44 |
| ▸ | NOS1 | P29475 | 1/20 | 0.44 |
| ▸ | CASP1 | P29466 | 1/20 | 0.44 |
| ▸ | CASP4 | P49662 | 1/20 | 0.44 |
| ▸ | CASP5 | P51878 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8631008 | 0.86 | RECQL (0.67) | RECQLP2RX7POLBHSD17B10L3MBTL1 | |
| SCHEMBL27566640 | 0.82 | RECQL (0.69) | RECQLP2RX7POLBKMOCYP1A2 | |
| SCHEMBL29520874 | 0.81 | RECQL (0.53) | RECQLP2RX7POLBHSD17B10L3MBTL1 | |
| SCHEMBL8633681 | 0.80 | RECQL (0.50) | RECQLP2RX7POLBHSD17B10L3MBTL1 | |
| SCHEMBL6977835 | 0.79 | RECQL (0.51) | RECQLP2RX7POLBHSD17B10L3MBTL1 | |
| SCHEMBL8628921 | 0.78 | POLB (0.58) | RECQLPOLBHSD17B10L3MBTL1KMO | |
| SCHEMBL8627836 | 0.75 | DRD4 (0.45) | RECQLP2RX7POLBHSD17B10L3MBTL1 | |
| SCHEMBL13150782 | 0.74 | SLC6A3 (0.83) | SLC6A3HTR1ADRD2SIGMAR1 | |
| SCHEMBL14407778 | 0.74 | SLC6A3 (0.83) | SLC6A3HTR1ADRD2SIGMAR1 | |
| SCHEMBL6056974 | 0.74 | SLC6A3 (0.83) | SLC6A3HTR1ADRD2SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5780475-A | Antipsychotic indazole derivatives | MERCK, SHARP & DOHME LIMITED (GB) | 1998-07-14 | — | — | US | disclosed |