Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RECQL | P46063 | 2/20 | 0.67 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.48 |
| ▸ | MC4R | P32245 | 1/20 | 0.46 |
| ▸ | KMO | O15229 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | DRD4 | P21917 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.44 |
| ▸ | HTR3B | O95264 | 2/20 | 0.44 |
| ▸ | HTR3A | P46098 | 2/20 | 0.44 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.44 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8633902 | 0.86 | RECQL (0.55) | RECQLSIGMAR1P2RX7KMOPOLB | |
| SCHEMBL29520874 | 0.83 | RECQL (0.53) | RECQLP2RX7KMOPOLBNPC1 | |
| SCHEMBL8633681 | 0.82 | RECQL (0.50) | RECQLSIGMAR1P2RX7KMOPOLB | |
| SCHEMBL6977835 | 0.81 | RECQL (0.51) | RECQLP2RX7KMOPOLBNPC1 | |
| SCHEMBL30346162 | 0.81 | RECQL (1.00) | RECQLKMT2AP2RX7KMOALDH1A1 | |
| SCHEMBL248214 | 0.81 | RECQL (1.00) | RECQLKMT2AP2RX7KMOALDH1A1 | |
| SCHEMBL8628921 | 0.80 | POLB (0.58) | RECQLKMT2AKMOPOLBLMNA | |
| SCHEMBL8631478 | 0.80 | ALDH1A1 (0.54) | KMT2APOLBLMNAALDH1A1HSD17B10 | |
| SCHEMBL8629425 | 0.78 | DRD4 (0.56) | RECQLPOLBDRD4LMNAALDH1A1 | |
| SCHEMBL8627836 | 0.77 | DRD4 (0.45) | RECQLKMT2AP2RX7POLBDRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5780475-A | Antipsychotic indazole derivatives | MERCK, SHARP & DOHME LIMITED (GB) | 1998-07-14 | — | — | US | disclosed |