SCHEMBL8633929

SCHEMBL8633929

NS(=O)(=O)Cc1ccccc1C1=NOCCO1

nearest known ligand 0.36

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
ALOX5AP P20292 1/20 0.36
FEN1 P39748 1/20 0.36
CA1 P00915 2/20 0.35
CA2 P00918 2/20 0.35
CA5A P35218 2/20 0.35
CA9 Q16790 2/20 0.35
CA12 O43570 1/20 0.34
LMNA P02545 1/20 0.34
CA3 P07451 1/20 0.34
CA4 P22748 1/20 0.34
CA6 P23280 1/20 0.34
MAOB P27338 1/20 0.34
CA7 P43166 1/20 0.34
CA13 Q8N1Q1 1/20 0.34
CA14 Q9ULX7 1/20 0.34
CA5B Q9Y2D0 1/20 0.34
PKM P14618 1/20 0.30
TSHR P16473 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8875554 0.87 HPGD (0.33) ALOX5APFEN1CA1CA2CA9
SCHEMBL8629661 0.80
SCHEMBL29469898 0.78 CA1 (0.38) ALOX5APFEN1CA1CA2CA5A
SCHEMBL7901217 0.78 CA1 (0.38) ALOX5APFEN1CA1CA2CA5A
SCHEMBL1576931 0.75 ALOX5AP (0.35) ALOX5APFEN1CA1CA2CA5A
SCHEMBL7840064 0.75 CYP2D6 (0.38) LMNAMAOB
SCHEMBL8633120 0.75 TAAR1 (0.34) CA1CA2TSHR
SCHEMBL3776593 0.71 CA1 (0.33) ALOX5APFEN1CA1CA2CA9
SCHEMBL8796098 0.70 CA1 (0.35) CA1CA2CA9CA12CA4
SCHEMBL7911258 0.70 PKM (0.36) CA1CA2CA9CA12PKM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5847126-A N-azinyl-N'-(het) arylsulphonyl-ureas BAYER AKTIENGESELLSCHAFT (DE) 1998-12-08 US disclosed
EP-0645386-B1 N-Azinyl-N'-(het)arylsulfonylureas as herbicides BAYER AG (DE) 1997-12-29 EP disclosed
US-5696257-A INTERMEDIATES FOR HERBICIDES BAYER AKTIENGESELLSCHAFT (DE) 1997-12-09 US disclosed
EP-0629604-B1 Alicyclic phospholipase A2 inhibitors BRISTOL MYERS SQUIBB CO (US) 1997-04-16 EP disclosed
US-5580842-A HERBICIDES BAYER AKTIENGESELLSCHAFT (DE) 1996-12-03 US disclosed
US-5476936-A Herbicides BAYER AKTIENGESELLSCHAFT (DE) 1995-12-19 US disclosed
US-5436369-A Alicyclic phospholipase A2 inhibitors BRISTOL-MYERS SQUIBB COMPANY (US) 1995-07-25 US disclosed
EP-0645386-A1 N-Azinyl-N'-(het)arylsulfonylureas as herbicides BAYER AG (DE) 1995-03-29 EP disclosed