Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.68 |
| ▸ | MEN1 | O00255 | 6/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.68 |
| ▸ | GAA | P10253 | 5/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.68 |
| ▸ | MAPT | P10636 | 3/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.68 |
| ▸ | TSHR | P16473 | 2/20 | 0.67 |
| ▸ | HTT | P42858 | 1/20 | 0.66 |
| ▸ | RAB9A | P51151 | 6/20 | 0.65 |
| ▸ | NPC1 | O15118 | 3/20 | 0.65 |
| ▸ | CASP3 | P42574 | 1/20 | 0.65 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.65 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.65 |
| ▸ | TP53 | P04637 | 1/20 | 0.65 |
| ▸ | POLB | P06746 | 1/20 | 0.65 |
| ▸ | CA1 | P00915 | 1/20 | 0.62 |
| ▸ | CA2 | P00918 | 1/20 | 0.62 |
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6339534 | 0.87 | SMN1; SMN2 (0.64) | SMN1; SMN2MEN1KMT2AGAAALDH1A1 | |
| SCHEMBL1615839 | 0.87 | SMN1; SMN2 (0.73) | SMN1; SMN2MEN1KMT2AGAAALDH1A1 | |
| SCHEMBL9422337 | 0.86 | SMN1; SMN2 (0.73) | SMN1; SMN2MEN1KMT2AGAAALDH1A1 | |
| Hydrochloric Acid SCHEMBL11683217 | 0.85 | SMN1; SMN2 (0.62) | SMN1; SMN2MEN1KMT2AGAAALDH1A1 | |
| SCHEMBL5879030 | 0.84 | RAB9A (0.88) | SMN1; SMN2MEN1KMT2AGAAALDH1A1 | |
| SCHEMBL10941324 | 0.84 | NAMPT (0.69) | SMN1; SMN2MEN1KMT2AGAAALDH1A1 | |
| SCHEMBL4289783 | 0.84 | HPGD (0.71) | SMN1; SMN2MEN1KMT2AGAAALDH1A1 | |
| SCHEMBL10943445 | 0.84 | RAB9A (0.88) | SMN1; SMN2MEN1KMT2AGAAALDH1A1 | |
| SCHEMBL7141724 | 0.83 | TSHR (0.72) | SMN1; SMN2MEN1KMT2AGAAALDH1A1 | |
| SCHEMBL9877349 | 0.83 | TSHR (0.67) | SMN1; SMN2MEN1KMT2AGAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230373932-A1 | DIHYDROPYRIMIDIN-2-ONE COMPOUNDS AND MEDICAL USE THEREOF | JAPAN TOBACCO INC. (JP) | 2023-11-23 | — | — | US | disclosed |
| CN-112574070-B | Synthesis method of substituted urea compound | 西华大学 | 2022-11-08 | — | — | CN | disclosed |
| US-20210130300-A1 | DIHYDROPYRIMIDIN-2-ONE COMPOUNDS AND MEDICAL USE THEREOF | JAPAN TOBACCO INC. (JP) | 2021-05-06 | — | — | US | disclosed |
| CN-112574070-A | Synthesis method of substituted urea compound | 西华大学 | 2021-03-30 | — | — | CN | disclosed |
| EP-3744713-A1 | DIYHYDROPYRIMIDINE-2-ONE COMPOUNDS AND MEDICINAL USES THEREOF | Japan Tobacco Inc. (JP) | 2020-12-02 | — | — | EP | disclosed |
| EP-3231793-B1 | DIHYDROPYRIMIDINE-2-ONE COMPOUNDS AND MEDICINAL USES THEREOF | JAPAN TOBACCO INC (JP) | 2020-03-11 | — | — | EP | disclosed |
| US-10196363-B2 | Dihydropyrimidin-2-one compounds and medical use thereof | JAPAN TOBACCO INC. (JP) | 2019-02-05 | — | — | US | disclosed |
| EP-3231793-A1 | DIHYDROPYRIMIDINE-2-ONE COMPOUNDS AND MEDICINAL USES THEREOF | JAPAN TOBACCO INC. (JP) | 2017-10-18 | — | — | EP | disclosed |
| US-20160194290-A1 | DIHYDROPYRIMIDIN-2-ONE COMPOUNDS AND MEDICAL USE THEREOF | SHIONOGI & CO., LTD. (JP) | 2016-07-07 | — | — | US | disclosed |
| CN-103228644-A | 4-substituted-cyclohexylamino-4-piperidinyl-acetamide antagonists of CCR2 | JANSSEN PHARMACEUTICA NV | 2013-07-31 | — | — | CN | disclosed |
| CN-1130351-C | 1,5-benzodiazepine derivatives | ZERIA PHARM CO LTD (JP) | 2003-12-10 | — | — | CN | disclosed |
| CN-1081636-C | Pyrrolyl quinoxalindiones, their production and use | BASF AG (DE) | 2002-03-27 | — | — | CN | disclosed |
| CN-1246850-A | 1,5-benzodiazepine derivatives | ZERIA PHARM CO LTD (JP) | 2000-03-08 | — | — | CN | disclosed |
| CN-1211980-A | Pyrrolyl quinoxalindiones, their production and use | BASF AG (DE) | 1999-03-24 | — | — | CN | disclosed |
| US-5637428-A | POSITIVE WORKING PHOTOSENSITIVE COMPOSITION | FUJI PHOTO FILM CO., LTD. (JP) | 1997-06-10 | — | — | US | disclosed |
| EP-0213326-B1 | 2,5-DIMETHYL PYRROLE DERIVATIVES, THEIR PREPARATION AND THEIR USE | CASSELLA Aktiengesellschaft (DE) | 1991-03-06 | — | — | EP | disclosed |
| US-4966901-A | FOR TREATMENT OF ALZHEIMER*S DISEASE, LEARNING OR MEMORY PROBLEMS | CASSELLA AKTIENGESELLSCHAFT (DE) | 1990-10-30 | — | — | US | disclosed |
| EP-0346683-A1 | Pyrrole derivatives, their preparation and their use | CASSELLA Aktiengesellschaft (DE) | 1989-12-20 | — | — | EP | disclosed |
| US-4837225-A | ENCEPHALOTROPIC AND PSYCHOTROPIC EFFECTS | CASSELL AKTIENGESELLSCHAFT (DE) | 1989-06-06 | — | — | US | disclosed |
| EP-0213326-A1 | 2,5-Dimethyl pyrrole derivatives, their preparation and their use | CASSELLA Aktiengesellschaft (DE) | 1987-03-11 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10196363-B2 | Dihydropyrimidin-2-one compounds and medical use thereof | REN, PKD2, ALPI | SMN1; SMN2 319/4885MEN1 38/4885KMT2A 2192/4885 |
| US-20160194290-A1 | DIHYDROPYRIMIDIN-2-ONE COMPOUNDS AND MEDICAL USE THEREOF | REN, PKD2, ALPI | SMN1; SMN2 319/4885MEN1 38/4885KMT2A 2192/4885 |
| US-20210130300-A1 | DIHYDROPYRIMIDIN-2-ONE COMPOUNDS AND MEDICAL USE THEREOF | REN, PKD2, ALPI | SMN1; SMN2 319/4885MEN1 38/4885KMT2A 2192/4885 |
| US-20230373932-A1 | DIHYDROPYRIMIDIN-2-ONE COMPOUNDS AND MEDICAL USE THEREOF | REN, PKD2, ALPI | SMN1; SMN2 319/4885MEN1 38/4885KMT2A 2192/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.