Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.71 |
| ▸ | RECQL | P46063 | 1/20 | 0.71 |
| ▸ | TSHR | P16473 | 2/20 | 0.69 |
| ▸ | RAB9A | P51151 | 6/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.67 |
| ▸ | MEN1 | O00255 | 5/20 | 0.67 |
| ▸ | GAA | P10253 | 4/20 | 0.67 |
| ▸ | NPC1 | O15118 | 3/20 | 0.67 |
| ▸ | MAPT | P10636 | 3/20 | 0.67 |
| ▸ | CASP3 | P42574 | 1/20 | 0.67 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.67 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.67 |
| ▸ | TP53 | P04637 | 1/20 | 0.67 |
| ▸ | POLB | P06746 | 1/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.65 |
| ▸ | PKM | P14618 | 1/20 | 0.65 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.65 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9422337 | 0.87 | SMN1; SMN2 (0.73) | HPGDRECQLTSHRRAB9ASMN1; SMN2 | |
| SCHEMBL813535 | 0.87 | HPGD (0.79) | HPGDRECQLRAB9ASMN1; SMN2KMT2A | |
| SCHEMBL5879030 | 0.86 | RAB9A (0.88) | TSHRRAB9ASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL10941324 | 0.86 | NAMPT (0.69) | HPGDRECQLTSHRRAB9ASMN1; SMN2 | |
| SCHEMBL10943445 | 0.86 | RAB9A (0.88) | TSHRRAB9ASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL7473283 | 0.86 | HPGD (0.67) | HPGDRECQLTSHRRAB9ASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL11161378 | 0.85 | HPGD (0.80) | HPGDRECQLTSHRRAB9ASMN1; SMN2 | |
| SCHEMBL5947516 | 0.85 | TSHR (0.77) | TSHRRAB9ASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL4915127 | 0.85 | MAPT (0.75) | TSHRRAB9ASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL6691604 | 0.85 | TSHR (0.72) | TSHRRAB9ASMN1; SMN2KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 41 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060110743-A1 | Drug evolution: drug design at hot spots | KONISHI YASUO | 2006-05-25 | — | — | US | claimed |
| WO-2002095393-A2 | DRUG EVOLUTION: DRUG DESIGN AT HOT SPOTS | NATIONAL RESEARCH COUNCIL OF CANADA (CA) | 2002-11-28 | — | — | WO | claimed |
| US-11827640-B2 | Substituted pyrazolo[1,5-a]pyrimidines as CFTR modulators | ILDONG PHARMACEUTICAL CO., LTD. (KR) | 2023-11-28 | — | — | US | disclosed |
| US-11806337-B2 | Small molecule activators of nicotinamide phosphoribosyltransferase (NAMPT) and uses thereof | Sanford Burnham Prebys Medical Discovery Institute (US) | 2023-11-07 | — | — | US | disclosed |
| CN-113671082-A | Gas chromatography-ultra-high resolution mass spectrometry-based method for screening migration hazards in gutta-percha | 中国检验检疫科学研究院 | 2021-11-19 | — | — | CN | disclosed |
| WO-2021155253-A1 | ANAT INHIBITORS AND METHODS OF USE THEREOF | Atomwise Inc. (US) | 2021-08-05 | — | — | WO | disclosed |
| EP-3661495-A1 | COMPOSITIONS FOR USE FOR TREATING CUTANEOUS LEISHMANIASIS | BIONOOX SA (CH) | 2020-06-10 | — | — | EP | disclosed |
| US-20200155503-A1 | COMPOSITIONS FOR USE FOR TREATING CUTANEOUS LEISHMANIASIS | BIONOOX SA (CH) | 2020-05-21 | — | — | US | disclosed |
| CN-110996939-A | Compositions for use in methods of treating cutaneous leishmaniasis | 诺克斯生物公司 | 2020-04-10 | — | — | CN | disclosed |
| WO-2019025606-A1 | COMPOSITIONS FOR USE FOR TREATING CUTANEOUS LEISHMANIASIS | BIONOOX SA (CH) | 2019-02-07 | — | — | WO | disclosed |
| US-20170129863-A1 | IMINOSYDNONE DERIVATIVES FOR CONJUGATION AND RELEASE OF COMPOUNDS OF INTEREST | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2017-05-11 | — | — | US | disclosed |
| CN-1295064-A | Novel tricyclic compounds and pharmaceutical compositions containing them | ASAHI CHEMICAL IND (JP) | 2001-05-16 | — | — | CN | disclosed |
| US-6214838-B1 | WHICH ARE STABLE TO METABOLISM BY THE BODY AND EXHIBITS ANTI-INFLAMMATORY ACTIVITY, BONE RESORPTION INHIBITORY ACTIVITY AND ACTIVITY IN INHIBITING PRODUCTION OF IMMUNOCYTOKINES | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2001-04-10 | — | — | US | disclosed |
| EP-1087977-A1 | THIENODIPYRIDINE DERIVATIVES, PRODUCTION AND USE THEREOF | Takeda Chemical Industries, Ltd. (JP) | 2001-04-04 | — | — | EP | disclosed |
| WO-1999065916-A1 | THIENODIPYRIDINE DERIVATIVES, PRODUCTION AND USE THEREOF | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1999-12-23 | — | — | WO | disclosed |
| CN-1168675-A | Novel compounds | FUJISAWA PHARMACEUTICAL CO (JP) | 1997-12-24 | — | — | CN | disclosed |
| US-5602277-A | Substituted benzene derivatives useful as neuraminidase inhibitors | BIOCRYST PHARMACEUTICALS, INC. (US) | 1997-02-11 | — | — | US | disclosed |
| WO-1996030329-A1 | SUBSTITUTED BENZENE DERIVATIVES USEFUL AS NEURAMINIDASE INHIBITORS | BIOCRYST PHARMACEUTICALS, INCORPORATED (US) | 1996-10-03 | — | — | WO | disclosed |
| US-5286728-A | Amino-substituted piperazine derivatives | CIBA-GEIGY CORPORATION (US) | 1994-02-15 | — | — | US | disclosed |
| US-4183931-A | SEDATIVE-HYPNOTICS, ANTICONVULSANTS, CENTRAL NERVOUS SYSTEM DEPRESSANTS | RESEARCH CORPORATION (US) | 1980-01-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11827640-B2 | Substituted pyrazolo[1,5-a]pyrimidines as CFTR modulators | PDE4A, PDE4B, PDE5A | HPGD 312/4885RECQL 59/4885TSHR 2647/4885 |
| US-20200155503-A1 | COMPOSITIONS FOR USE FOR TREATING CUTANEOUS LEISHMANIASIS | KEAP1, CYP46A1, IL1B | HPGD 228/4885RECQL 923/4885TSHR 4791/4885 |
| US-11806337-B2 | Small molecule activators of nicotinamide phosphoribosyltransferase (NAMPT) and uses thereof | NAMPT, NAPRT, NNT | HPGD 139/4885RECQL 2693/4885TSHR 3541/4885 |
| US-20170129863-A1 | IMINOSYDNONE DERIVATIVES FOR CONJUGATION AND RELEASE OF COMPOUNDS OF INTEREST | IPO5, IDE, IMPDH1 | HPGD 165/4885RECQL 978/4885TSHR 3655/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.