Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 3/20 | 0.38 |
| ▸ | PDE9A | O76083 | 1/20 | 0.37 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 2/20 | 0.35 |
| ▸ | CA2 | P00918 | 2/20 | 0.35 |
| ▸ | CA4 | P22748 | 2/20 | 0.35 |
| ▸ | CA9 | Q16790 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 4/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | NRP1 | O14786 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8628555 | 0.90 | KDM4E (0.38) | PTGS2CA1CA2CA9HPGD | |
| SCHEMBL8635045 | 0.90 | PDE9A (0.42) | PTGS2PDE9APDE1CHPGDCYP2C9 | |
| SCHEMBL8632173 | 0.87 | F10 (0.36) | PTGS2CA2CA9HPGDCYP2C9 | |
| SCHEMBL8631591 | 0.87 | PTGS2 (0.41) | PTGS2CA1CA2CA4CA9 | |
| SCHEMBL7777626 | 0.86 | PTGS2 (0.48) | PTGS2CA1CA2CA4CA9 | |
| SCHEMBL8629079 | 0.86 | F10 (0.36) | PTGS2CA1CA2CA9HPGD | |
| SCHEMBL8633616 | 0.83 | PTGS2 (0.39) | PTGS2CA1CA2CA4CA9 | |
| SCHEMBL8634717 | 0.83 | PTGS2 (0.43) | PTGS2F10P2RX3 | |
| SCHEMBL8631787 | 0.83 | PTGS2 (0.40) | PTGS2CA1CA2CA4CA9 | |
| SCHEMBL7780107 | 0.81 | PTGS2 (0.58) | PTGS2CYP2C9CYP2C19POLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5756530-A | NON-STEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G. D. SEARLE & CO. (US) | 1998-05-26 | — | — | US | disclosed |