Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | DHODH | Q02127 | 4/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.34 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.34 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8417917 | 0.92 | TSHR (0.39) | MEN1POLBKMT2ASMN1; SMN2CYP2C9 | |
| SCHEMBL8421711 | 0.91 | AGTR1 (0.41) | KDM4EKMT2ASMN1; SMN2CYP2C9ABCB11 | |
| SCHEMBL8419029 | 0.90 | AGTR1 (0.37) | CYP2C9ABCB11EGFRERBB2CYP3A4 | |
| SCHEMBL8419094 | 0.86 | MAPT (0.37) | KDM4EPOLBSMN1; SMN2DHODHRECQL | |
| SCHEMBL8419225 | 0.86 | DHODH (0.35) | POLBDHODHRECQL | |
| SCHEMBL8417426 | 0.85 | TSHR (0.37) | MEN1POLBKMT2ACYP2C9ABCB11 | |
| SCHEMBL8422155 | 0.84 | DHODH (0.38) | KDM4EPOLBDHODHRECQL | |
| SCHEMBL7235119 | 0.84 | DHODH (0.43) | KDM4EDHODHCYP2C9ABCB11EGFR | |
| SCHEMBL8417957 | 0.84 | ALOX15 (0.41) | KDM4EPOLBSMN1; SMN2CYP2C9ABCB11 | |
| SCHEMBL8418031 | 0.84 | ABCB11 (0.34) | DHODHCYP2C9ABCB11EGFRERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5763619-A | HYPOTENSIVE AGENTS, CARDIOVASCULAR DISORDERS OR STROKES | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-06-09 | — | — | US | disclosed |
| US-5705517-A | ANGIOTENSIN II ANTAGONISTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-01-06 | — | — | US | disclosed |
| US-5703110-A | HYPOTENSIVE AGENTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1997-12-30 | — | — | US | disclosed |