Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8418031 | 0.91 | ABCB11 (0.34) | DHODH | |
| SCHEMBL8421733 | 0.89 | ALDH1A1 (0.35) | — | |
| SCHEMBL8421085 | 0.89 | ALOX15 (0.40) | POLB | |
| SCHEMBL8419094 | 0.86 | MAPT (0.37) | DHODHRECQLHSD17B10MAPK1POLB | |
| SCHEMBL8635498 | 0.86 | KDM4E (0.37) | DHODHRECQLPOLB | |
| SCHEMBL8421711 | 0.84 | AGTR1 (0.41) | — | |
| SCHEMBL8422155 | 0.84 | DHODH (0.38) | DHODHRECQLHSD17B10MAPK1POLB | |
| SCHEMBL7235119 | 0.84 | DHODH (0.43) | DHODHHSD17B10 | |
| SCHEMBL8417950 | 0.84 | ALOX15 (0.35) | DHODHHSD17B10MAPK1 | |
| SCHEMBL8419029 | 0.83 | AGTR1 (0.37) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5962491-A | ANGIOTENSIN ANTAGONIST, HYPOTENSIVE AGENTS, CARDIOVASCULAR DISORDERS, STROKES | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1999-10-05 | — | — | US | disclosed |
| US-5705517-A | ANGIOTENSIN II ANTAGONISTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-01-06 | — | — | US | disclosed |