Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B1 | P14061 | 4/20 | 0.60 |
| ▸ | PTPRC | P08575 | 1/20 | 0.56 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.56 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.53 |
| ▸ | PARP1 | P09874 | 1/20 | 0.53 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.53 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.51 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | GRM5 | P41594 | 1/20 | 0.47 |
| ▸ | CASP1 | P29466 | 1/20 | 0.47 |
| ▸ | CASP7 | P55210 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | DHODH | Q02127 | 1/20 | 0.44 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.43 |
| ▸ | PGR | P06401 | 1/20 | 0.43 |
| ▸ | TNKS | O95271 | 1/20 | 0.42 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.42 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8072264 | 0.90 | HRH3 (0.54) | HSD17B1PTPRCPTPN1HRH3PARP1 | |
| SCHEMBL8635876 | 0.90 | HSD17B1 (0.56) | HSD17B1PTPRCPTPN1HRH3PARP1 | |
| SCHEMBL8631353 | 0.87 | PTPRC (0.56) | HSD17B1PTPRCPTPN1HRH3PARP1 | |
| SCHEMBL5937022 | 0.80 | HSD17B1 (0.63) | HSD17B1CYP11B1CYP11B2CYP1A2GRM5 | |
| SCHEMBL8635273 | 0.80 | PTPRC (0.46) | HSD17B1PTPRCPTPN1HRH3PARP1 | |
| SCHEMBL8635928 | 0.80 | PARP1 (0.48) | HSD17B1PTPRCPTPN1HRH3PARP1 | |
| SCHEMBL28655414 | 0.80 | HSD17B1 (0.78) | HSD17B1HRH3CYP11B1CYP11B2CYP1A2 | |
| SCHEMBL28841436 | 0.80 | HSD17B1 (0.50) | HSD17B1CYP11B1CYP11B2CYP1A2GRM5 | |
| SCHEMBL1745161 | 0.79 | HSD17B1 (0.71) | HSD17B1HRH3CYP11B1CYP11B2CYP1A2 | |
| SCHEMBL8155829 | 0.78 | PARP11 (0.68) | PTPRCPTPN1HRH3PARP1PARP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0601191-B1 | NOVEL TETRACYCLIC COMPOUND | KYOWA HAKKO KOGYO KK (JP) | 1998-07-22 | — | — | EP | disclosed |
| US-5371225-A | Immunosuppressants | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1994-12-06 | — | — | US | disclosed |
| EP-0601191-A1 | NOVEL TETRACYCLIC COMPOUND | KYOWA HAKKO KOGYO KABUSHIKI KAISHA (JP) | 1994-06-15 | — | — | EP | disclosed |