Hydrochloric Acid

Hydrochloric Acid

SCHEMBL8635888

CC1=Cc2c(ccc3ccccc23)C1[Zr+2]1(C2C(C)=Cc3c2ccc2ccccc32)=[Si]2C=C[Si]=1C=C2.[Cl-].[Cl-]

nearest known ligand 0.34

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Known targets — ChEMBL curated mechanism

ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA

The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 2/20 0.34
CYP2A6 P11509 4/20 0.33
ALDH1A1 P00352 3/20 0.33
CYP1A2 P05177 2/20 0.32
TSHR P16473 2/20 0.32
MAPT P10636 1/20 0.32
ALOX12 P18054 1/20 0.32
MEN1 O00255 1/20 0.31
KMT2A Q03164 1/20 0.31
HSD17B10 Q99714 2/20 0.31
HPGD P15428 1/20 0.31
POLB P06746 1/20 0.31
TDP1 Q9NUW8 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL8632945 0.84 KDM4E (0.38) KDM4ECYP2A6ALDH1A1CYP1A2TSHR
Hydrochloric Acid SCHEMBL8633679 0.84 KDM4E (0.33) KDM4ECYP2A6ALDH1A1CYP1A2TSHR
Hydrochloric Acid SCHEMBL6553946 0.79 KDM4E (0.38) KDM4ECYP2A6ALDH1A1CYP1A2TSHR
Hydrochloric Acid SCHEMBL388936 0.79 KDM4E (0.38) KDM4ECYP2A6ALDH1A1CYP1A2TSHR
Hydrochloric Acid SCHEMBL6554982 0.79 KDM4E (0.38) KDM4ECYP2A6ALDH1A1CYP1A2TSHR
Hydrochloric Acid SCHEMBL7933297 0.78 MEN1 (0.38) KDM4ECYP2A6ALDH1A1CYP1A2TSHR
Hydrochloric Acid SCHEMBL5068152 0.77 KDM4E (0.36) KDM4ECYP2A6ALDH1A1CYP1A2TSHR
Hydrochloric Acid SCHEMBL673327 0.77 KDM4E (0.36) KDM4ECYP2A6ALDH1A1CYP1A2TSHR
Fluoride Ion SCHEMBL7641950 0.77 KDM4E (0.38) KDM4ECYP2A6ALDH1A1CYP1A2TSHR
Hydrochloric Acid SCHEMBL2860800 0.76 MEN1 (0.36) KDM4ECYP2A6ALDH1A1CYP1A2TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5776851-A COORDINATION POLYMERIZATION CATALYST TARGOR GMBH (DE) 1998-07-07 US claimed
US-5776851-A COORDINATION POLYMERIZATION CATALYST TARGOR GMBH (DE) 1998-07-07 US disclosed
US-5693730-A METALLOCENES HAVING MORE THAN ONE CENTRAL ATOM AND A SPECIAL BRIDGE STRUCTURE FOR PREPARING ISOTACTIC, HIGH-MOLECULAR-WEIGHT POLYMERS HAVING GOOD GRAIN MORPHOLOGY; PROPYLENE HOMO- AND COPOLYMERS HOECHST AKTIENGESELLSCHAFT (DE) 1997-12-02 US disclosed