Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.33 |
| ▸ | CYP2A6 | P11509 | 4/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 3/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | KDM1A | O60341 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | DRD2 | P14416 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
| ▸ | SLC18A2 | Q05940 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5068152 | 0.97 | KDM4E (0.36) | KDM4EALDH1A1CYP2A6CYP1A2TSHR | |
| Hydrochloric Acid SCHEMBL388936 | 0.94 | KDM4E (0.38) | KDM4EALDH1A1CYP2A6CYP1A2TSHR | |
| Fluoride Ion SCHEMBL7641950 | 0.91 | KDM4E (0.38) | KDM4EALDH1A1CYP2A6CYP1A2TSHR | |
| Hydrochloric Acid SCHEMBL6886266 | 0.84 | HTR7 (0.34) | ALDH1A1CYP2A6MAPTKDM1ADRD2 | |
| Hydrochloric Acid SCHEMBL6892837 | 0.82 | KDM4E (0.36) | KDM4EALDH1A1CYP2A6CYP1A2TSHR | |
| Hydrochloric Acid SCHEMBL5951783 | 0.81 | HTR7 (0.35) | ALDH1A1CYP2A6MAPTKDM1ADRD2 | |
| Hydrochloric Acid SCHEMBL6891775 | 0.80 | KDM4E (0.34) | KDM4E | |
| Hydrochloric Acid SCHEMBL6895207 | 0.80 | KDM4E (0.34) | KDM4ESLC6A4SLC18A2 | |
| Hydrochloric Acid SCHEMBL6893714 | 0.80 | KDM4E (0.39) | KDM4EALDH1A1MAPTHPGDGAA | |
| Hydrochloric Acid SCHEMBL6553946 | 0.79 | KDM4E (0.38) | KDM4EALDH1A1CYP2A6CYP1A2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 57 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1053263-B1 | CATALYST SYSTEM | BASELL POLYOLEFINE GMBH (DE) | 2003-10-01 | — | — | EP | claimed |
| EP-1058694-B1 | Catalyst system, method for its production and its use for the polymerisation of olefins | BASELL POLYOLEFINE GMBH (DE) | 2003-04-09 | — | — | EP | claimed |
| US-6482902-B1 | Catalyst system | TARGOR GMBH (DE) | 2002-11-19 | — | — | US | claimed |
| US-6391989-B1 | COORDINATION CATALYST ON SUPPORT; POLYMERIZATION OF ALPHA-OLEFINS | BASELL POLYPROPYLEN GMBH (DE) | 2002-05-21 | — | — | US | claimed |
| EP-1648946-B1 | OLEFIN POLYMERIZATION PROCESS | BASELL POLYOLEFINE GMBH (DE) | 2015-07-15 | — | — | EP | disclosed |
| US-8058350-B2 | Polypropylene composition | Basell Poliolefine Italia, s.r.l. (IT) | 2011-11-15 | — | — | US | disclosed |
| EP-1680468-B1 | POLYPROPYLENE COMPOSITION | BASELL POLIOLEFINE SRL (IT) | 2011-08-17 | — | — | EP | disclosed |
| EP-1620448-B1 | PROCESS FOR THE PRODUCTION OF HALIDE METALLOCENE COMPOUNDS | BASELL POLYOLEFINE GMBH (DE) | 2010-06-16 | — | — | EP | disclosed |
| US-7468451-B2 | Process for the production of halide metallocene compounds | BASELL POLYOLEFINE GMBH (DE) | 2008-12-23 | — | — | US | disclosed |
| US-7465688-B2 | Process for the isomerization of metallocene compounds | BASELL POLYOLEFINE GMBH (DE) | 2008-12-16 | — | — | US | disclosed |
| US-20080160862-A1 | Polyolefin Composition, Fibres and Nonwoven Fabrics | BASELL POLIOLEFINE ITALIA S.R.L. (IT) | 2008-07-03 | — | — | US | disclosed |
| EP-1381618-B1 | PROCESS FOR THE PRODUCTION OF MONOHALIDE OR DIHALIDE METALLOCENE COMPOUNDS | BASELL POLYOLEFINE GMBH (DE) | 2008-05-07 | — | — | EP | disclosed |
| US-6482902-B1 | Catalyst system | TARGOR GMBH (DE) | 2002-11-19 | — | — | US | disclosed |
| WO-2002083699-A2 | PROCESS FOR THE PRODUCTION OF MONOHALIDE OR DIHALIDE METALLOCENE COMPOUNDS | BASELL POLYOLEFINE GMBH (DE) | 2002-10-24 | — | — | WO | disclosed |
| US-6417302-B1 | REACTION PRODUCT OF DI(PENTAFLUOROPHENYL) BORINIC ACID AND ORGANOALUMINUM COMPOUND; OLEFIN POLYMERIZATION COORDINATION CATALYSTS | BASELL POLYOLEFINE GMBH (DE) | 2002-07-09 | — | — | US | disclosed |
| US-6407189-B1 | USING ORGANOMETALLIC COMPOUNDS AS CATALYST | CLARIANT GMBH (DE) | 2002-06-18 | — | — | US | disclosed |
| US-6391989-B1 | COORDINATION CATALYST ON SUPPORT; POLYMERIZATION OF ALPHA-OLEFINS | BASELL POLYPROPYLEN GMBH (DE) | 2002-05-21 | — | — | US | disclosed |
| US-20020058765-A1 | Catalyst system for the polymerization of olefins | BAYER AKTIENGESELLSCHAFT (DE) | 2002-05-16 | — | — | US | disclosed |
| US-6271164-B1 | METALLOCENE CATALYST | LYONDELL CHEMICAL TECHNOLOGY, L.P. | 2001-08-07 | — | — | US | disclosed |
| US-6177526-B1 | METALLOCENE; COCATALYST; MODIFIED OXIDE CONTAINS ORGANIC SILICON RADICALS CONTAINING AT LEAST ONE OF THE GROUPS NITROGEN, FLUORINE, PHOSPHORUS OR SULFUR. | TARGOR GMBH (DE) | 2001-01-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020058765-A1 | Catalyst system for the polymerization of olefins | MAOA, MAOB, MSMO1 | KDM4E 290/4885ALDH1A1 2424/4885CYP2A6 118/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.