Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | CYP2A6 | P11509 | 4/20 | 0.35 |
| ▸ | TSHR | P16473 | 3/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.33 |
| ▸ | HPGD | P15428 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fluoride Ion SCHEMBL7641950 | 0.97 | KDM4E (0.38) | KDM4EALDH1A1CYP2A6TSHRCYP1A2 | |
| Hydrochloric Acid SCHEMBL5068152 | 0.94 | KDM4E (0.36) | KDM4EALDH1A1CYP2A6TSHRCYP1A2 | |
| Hydrochloric Acid SCHEMBL673327 | 0.94 | KDM4E (0.36) | KDM4EALDH1A1CYP2A6TSHRCYP1A2 | |
| Hydrochloric Acid SCHEMBL5951783 | 0.86 | HTR7 (0.35) | ALDH1A1CYP2A6MAPTKDM1ASLC6A4 | |
| Fluoride Ion SCHEMBL7640470 | 0.83 | HTR7 (0.35) | KDM4EALDH1A1CYP2A6HPGDMAPT | |
| Hydrochloric Acid SCHEMBL1030910 | 0.82 | CYP1A2 (0.37) | KDM4EALDH1A1CYP2A6CYP1A2HSD17B10 | |
| Hydrochloric Acid SCHEMBL6554982 | 0.82 | KDM4E (0.38) | KDM4EALDH1A1CYP2A6TSHRCYP1A2 | |
| Hydrochloric Acid SCHEMBL6553946 | 0.82 | KDM4E (0.38) | KDM4EALDH1A1CYP2A6TSHRCYP1A2 | |
| Hydrochloric Acid SCHEMBL6891404 | 0.81 | KDM4E (0.36) | KDM4EKDM1ASLC6A4DRD2POLB | |
| Hydrochloric Acid SCHEMBL2860800 | 0.81 | MEN1 (0.36) | KDM4EALDH1A1CYP2A6TSHRCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 69 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1053263-B1 | CATALYST SYSTEM | BASELL POLYOLEFINE GMBH (DE) | 2003-10-01 | — | — | EP | claimed |
| EP-1058694-B1 | Catalyst system, method for its production and its use for the polymerisation of olefins | BASELL POLYOLEFINE GMBH (DE) | 2003-04-09 | — | — | EP | claimed |
| US-6482902-B1 | Catalyst system | TARGOR GMBH (DE) | 2002-11-19 | — | — | US | claimed |
| US-6410665-B1 | POLYMERIZATION COORDINATION CATALYST FOR ALPHA-OLEFIN | BASELL POLYOLEFINE GMBH (DE) | 2002-06-25 | — | — | US | claimed |
| US-6391989-B1 | COORDINATION CATALYST ON SUPPORT; POLYMERIZATION OF ALPHA-OLEFINS | BASELL POLYPROPYLEN GMBH (DE) | 2002-05-21 | — | — | US | claimed |
| US-6124231-A | Supported catalyst system, processes for its preparation, and its use for the polymerization of olefins | TARGOR GMBH (DE) | 2000-09-26 | — | — | US | claimed |
| US-5932669-A | HOMO OR COPOLYMERIZING OLEFIN IN PRESENCE OF TRANSITIONAL METAL COMPOUND AS A METALLOCENE CATALYST AND ALUMINOXANE AS COCATALYST | TARGOR GMBH (DE) | 1999-08-03 | — | — | US | claimed |
| US-5455366-A | Olefin polymerization catalysts | HOECHST AG (DE) | 1995-10-03 | — | — | US | claimed |
| EP-0783022-B2 | ETHYLENIC POLYMER COMPOSITION | MITSUI CHEMICALS INC (JP) | 2016-01-20 | — | — | EP | disclosed |
| US-8101695-B2 | Propylene based terpolymers | BASELL POLYOLEFINE GMBH (DE) | 2012-01-24 | — | — | US | disclosed |
| US-8058350-B2 | Polypropylene composition | Basell Poliolefine Italia, s.r.l. (IT) | 2011-11-15 | — | — | US | disclosed |
| EP-1680468-B1 | POLYPROPYLENE COMPOSITION | BASELL POLIOLEFINE SRL (IT) | 2011-08-17 | — | — | EP | disclosed |
| US-7531609-B2 | Process for the preparation of 1-butene/propylene copolymers | BASELL POYLOEFINE GMBH (DE) | 2009-05-12 | — | — | US | disclosed |
| US-7468451-B2 | Process for the production of halide metallocene compounds | BASELL POLYOLEFINE GMBH (DE) | 2008-12-23 | — | — | US | disclosed |
| US-5830821-A | POLYMERIZATION CATALYST | TARGOR GMBH (DE) | 1998-11-03 | — | — | US | disclosed |
| US-5770752-A | Process for reducing the concentration of by-products in product mixtures | TARGOR GMBH (DE) | 1998-06-23 | — | — | US | disclosed |
| EP-0692505-B1 | Process for procucing propylene block copolymers | MITSUBISHI CHEM CORP (JP) | 1998-01-28 | — | — | EP | disclosed |
| EP-0783022-A1 | ETHYLENIC POLYMER COMPOSITION | MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) | 1997-07-09 | — | — | EP | disclosed |
| US-5623022-A | VAPOR PHASE; USING COORDINATION CATALYST | MITSUBISHI CHEMICAL CORPORATION (JP) | 1997-04-22 | — | — | US | disclosed |
| EP-0692505-A2 | Process for procucing propylene block copolymers | MITSUBISHI CHEMICAL CORPORATION (JP) | 1996-01-17 | — | — | EP | disclosed |