Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7136199 | 0.83 | LTA4H (0.76) | LTA4HHRH3TSHR | |
| SCHEMBL8642317 | 0.82 | MEN1 (0.60) | LTA4HKDM4ELMNAL3MBTL1ALDH1A1 | |
| SCHEMBL8637337 | 0.76 | LTA4H (0.60) | LTA4HALDH1A1PKMNPC1MAPT | |
| SCHEMBL8637149 | 0.76 | LTA4H (0.44) | LTA4HKDM4ECYP1A2CYP2C9CYP2C19 | |
| SCHEMBL8639296 | 0.75 | ALDH1A1 (0.56) | KDM4EALDH1A1KMT2AMEN1PKM | |
| SCHEMBL8637144 | 0.70 | LTA4H (0.47) | LTA4HALDH1A1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL8635904 | 0.69 | LTA4H (0.41) | LTA4HCYP1A2CYP2C9CYP2C19 | |
| SCHEMBL7139263 | 0.68 | LTA4H (0.75) | LTA4HHRH3 | |
| SCHEMBL1900326 | 0.68 | LTA4H (1.00) | LTA4HHRH3 | |
| SCHEMBL7132081 | 0.67 | LTA4H (0.74) | LTA4HHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5723492-A | LTA4 hydrolase inhibitor pharmaceutical compositions and methods of use | G.D. SEARLE & CO. (US) | 1998-03-03 | — | — | US | disclosed |
| US-5719306-A | ANTIINFLAMMATORY AGENTS | G.D. SEARLE & CO. (US) | 1998-02-17 | — | — | US | disclosed |