Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 9/20 | 0.60 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | CCR8 | P51685 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8640062 | 0.87 | LTA4H (0.51) | LTA4HTSHRNPC1ALDH1A1RAB9A | |
| SCHEMBL22533378 | 0.78 | ABL1 (0.62) | LTA4HCCR8MAPTTSHRALDH1A1 | |
| SCHEMBL8635900 | 0.76 | LTA4H (0.52) | LTA4HPKMMAPTTSHRNPC1 | |
| SCHEMBL8642317 | 0.76 | MEN1 (0.60) | LTA4HPKMNPSR1MAPTNPC1 | |
| SCHEMBL1900326 | 0.75 | LTA4H (1.00) | LTA4HEGFR | |
| SCHEMBL8641935 | 0.73 | LTA4H (0.61) | LTA4HCCR8EGFR | |
| SCHEMBL8637340 | 0.72 | LTA4H (0.63) | LTA4HCCR8EGFR | |
| SCHEMBL8201553 | 0.71 | LTA4H (0.67) | LTA4HPKMNPSR1CCR8MAPT | |
| SCHEMBL8046203 | 0.71 | LTA4H (0.67) | LTA4HPKMNPSR1MAPTTSHR | |
| SCHEMBL8639296 | 0.70 | ALDH1A1 (0.56) | PKMCCR8MAPTTSHRNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5723492-A | LTA4 hydrolase inhibitor pharmaceutical compositions and methods of use | G.D. SEARLE & CO. (US) | 1998-03-03 | — | — | US | disclosed |
| US-5719306-A | ANTIINFLAMMATORY AGENTS | G.D. SEARLE & CO. (US) | 1998-02-17 | — | — | US | disclosed |