Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 15/20 | 0.47 |
| ▸ | CHRNB4 | P30926 | 14/20 | 0.47 |
| ▸ | CHRNA3 | P32297 | 14/20 | 0.47 |
| ▸ | CHRNA10 | Q9GZZ6 | 7/20 | 0.46 |
| ▸ | CHRNA9 | Q9UGM1 | 7/20 | 0.46 |
| ▸ | CHRNB2 | P17787 | 10/20 | 0.46 |
| ▸ | CHRNA4 | P43681 | 10/20 | 0.46 |
| ▸ | RELA | Q04206 | 1/20 | 0.45 |
| ▸ | LTA4H | P09960 | 1/20 | 0.44 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | THPO | P40225 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7246918 | 0.87 | CARM1 (0.40) | CHRNA7CHRNB4CHRNA3CHRNB2CHRNA4 | |
| SCHEMBL4322788 | 0.83 | MEN1 (0.39) | — | |
| SCHEMBL8641764 | 0.82 | HRH3 (0.50) | LTA4H | |
| SCHEMBL7397894 | 0.82 | MAOA (0.47) | CHRNA7CHRNB4CHRNA3CHRNA10CHRNA9 | |
| Hydrochloric Acid SCHEMBL7402438 | 0.81 | MAOA (0.46) | CHRNA7CHRNB4CHRNA3CHRNA10CHRNA9 | |
| SCHEMBL8641777 | 0.80 | HRH3 (0.57) | CHRNA7CHRNB2CHRNA4LTA4H | |
| SCHEMBL8147094 | 0.79 | ATM (0.44) | CHRNA7CHRNB2CHRNA4 | |
| SCHEMBL8637445 | 0.78 | HRH1 (0.46) | LTA4H | |
| SCHEMBL11277901 | 0.77 | HRH3 (0.42) | — | |
| SCHEMBL8640957 | 0.75 | LTA4H (0.41) | LTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5723492-A | LTA4 hydrolase inhibitor pharmaceutical compositions and methods of use | G.D. SEARLE & CO. (US) | 1998-03-03 | — | — | US | disclosed |
| US-5719306-A | ANTIINFLAMMATORY AGENTS | G.D. SEARLE & CO. (US) | 1998-02-17 | — | — | US | disclosed |