Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.37 |
| ▸ | MCHR2 | Q969V1 | 1/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.36 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8644129 | 0.89 | LMNA (0.41) | LTA4HLMNAALDH1A1RECQLSMN1; SMN2 | |
| SCHEMBL8640526 | 0.85 | LMNA (0.48) | LMNARECQLSMN1; SMN2HRH3 | |
| SCHEMBL8147094 | 0.81 | ATM (0.44) | KDM4ERECQLHRH3 | |
| SCHEMBL7246918 | 0.80 | CARM1 (0.40) | MCHR2MCHR1SMN1; SMN2 | |
| SCHEMBL8637775 | 0.77 | MAOA (0.44) | LTA4HKMT2AALDH1A1SMN1; SMN2HRH3 | |
| SCHEMBL8639297 | 0.77 | SCN9A (0.42) | KMT2ALMNASCN9AALDH1A1SMN1; SMN2 | |
| SCHEMBL8636128 | 0.76 | MAOB (0.56) | — | |
| SCHEMBL8641764 | 0.76 | HRH3 (0.50) | LTA4HHRH3 | |
| SCHEMBL4322788 | 0.76 | MEN1 (0.39) | KMT2ASMN1; SMN2 | |
| SCHEMBL7403861 | 0.76 | KMT2A (0.44) | LTA4HKMT2ALMNAALDH1A1HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5723492-A | LTA4 hydrolase inhibitor pharmaceutical compositions and methods of use | G.D. SEARLE & CO. (US) | 1998-03-03 | — | — | US | disclosed |
| US-5719306-A | ANTIINFLAMMATORY AGENTS | G.D. SEARLE & CO. (US) | 1998-02-17 | — | — | US | disclosed |