SCHEMBL8636014

SCHEMBL8636014

CCOc1ccc(Sc2ccc(OCC=C(Cl)Cl)c(Br)c2)cc1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
POLB P06746 2/20 0.43
NPC1 O15118 1/20 0.43
RAB9A P51151 1/20 0.43
HTT P42858 1/20 0.38
MAPT P10636 6/20 0.35
TDP1 Q9NUW8 2/20 0.35
HPGD P15428 2/20 0.35
L3MBTL1 Q9Y468 1/20 0.35
NQO1 P15559 1/20 0.34
PTGIR P43119 1/20 0.33
TSHR P16473 1/20 0.33
ALDH1A1 P00352 3/20 0.33
PKM P14618 1/20 0.33
DPP4 P27487 1/20 0.33
GAA P10253 2/20 0.32
SMN1; SMN2 Q16637 1/20 0.32
KDM4E B2RXH2 2/20 0.32
LMNA P02545 1/20 0.32
NPSR1 Q6W5P4 1/20 0.32
HSD17B10 Q99714 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8632449 0.92 HTT (0.41) POLBNPC1RAB9AHTTMAPT
SCHEMBL8631583 0.89 NPC1 (0.41) POLBNPC1RAB9AMAPTTDP1
SCHEMBL8632153 0.86 PLAU (0.35) POLBNPC1RAB9AHTTMAPT
SCHEMBL8632079 0.85 MAPT (0.39) NPC1RAB9AMAPTTDP1HPGD
SCHEMBL8638417 0.83 HTT (0.36) POLBNPC1RAB9AHTTMAPT
SCHEMBL8635944 0.81 MTNR1A (0.35) NPC1RAB9AHTTMAPTTDP1
SCHEMBL8636447 0.75 PLAU (0.36) POLBNPC1RAB9AMAPTHPGD
SCHEMBL8635450 0.74 ALDH1A1 (0.44) HTTMAPTTDP1HPGDL3MBTL1
SCHEMBL8635615 0.74 MAPT (0.39) NPC1RAB9AMAPTTDP1HPGD
SCHEMBL8633489 0.74 GABRA1 (0.34) POLBRAB9AMAPTTDP1NQO1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0648729-B1 Dihalopropene compound, insecticide/acaricide containing said dihalopropene compound as active ingredient and intermediate compound for use in production of said dihalopropene compound SUMITOMO CHEMICAL CO (JP) 1998-07-15 EP disclosed
US-5698702-A INTERMEDIATES FOR INSECTICIDES, ACARICIDES SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1997-12-16 US disclosed
US-5530015-A Dihaloprene compound, insecticide/acaricide containing said dihalopropene compound as active ingredient, and intermediate compound for use in production of said dihalopropene compound SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1996-06-25 US disclosed
EP-0648729-A1 Dihalopropene compound, insecticide/acaricide containing said dihalopropene compound as active ingredient and intermediate compound for use in production of said dihalopropene compound SUMITOMO CHEMICAL COMPANY LIMITED (JP) 1995-04-19 EP disclosed