SCHEMBL8636591

SCHEMBL8636591

CCOc1cccc(Oc2ccc(OCC=C(Cl)Cl)c(C(F)(F)F)c2)c1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPK1 P28482 3/20 0.43
AR P10275 4/20 0.41
CTSS P25774 1/20 0.39
L3MBTL1 Q9Y468 3/20 0.37
MAPT P10636 2/20 0.37
LMNA P02545 2/20 0.37
ATM Q13315 1/20 0.37
RXRA P19793 1/20 0.37
RXRB P28702 1/20 0.37
RXRG P48443 1/20 0.37
ACACB O00763 1/20 0.36
ACACA Q13085 1/20 0.36
PDK2 Q15119 1/20 0.36
CETP P11597 1/20 0.36
LTA4H P09960 1/20 0.35
KMT2A Q03164 2/20 0.35
PDE3B Q13370 1/20 0.35
PDE3A Q14432 1/20 0.35
MEN1 O00255 1/20 0.35
USP2 O75604 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8635779 0.93 AR (0.39) MAPK1ARCTSSMAPTKMT2A
SCHEMBL8635048 0.92 MAPT (0.44) ARCTSSL3MBTL1MAPTLMNA
SCHEMBL8633011 0.90 MAPT (0.43) ARL3MBTL1MAPTLMNAATM
SCHEMBL8638861 0.90 AR (0.38) ARMAPTKMT2AMEN1ALDH1A1
SCHEMBL8636967 0.89 MAPK1 (0.43) MAPK1ARCTSSL3MBTL1MAPT
SCHEMBL8634174 0.87 AR (0.39) ARPDK2
SCHEMBL8635499 0.87 FFAR4 (0.43) ARRXRARXRBRXRGCETP
SCHEMBL8633895 0.86 AR (0.51) AR
SCHEMBL8633081 0.86 MAOB (0.43) ARL3MBTL1RXRARXRBRXRG
SCHEMBL8638742 0.85 FFAR1 (0.37) ARL3MBTL1CETPLTA4HALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0648729-B1 Dihalopropene compound, insecticide/acaricide containing said dihalopropene compound as active ingredient and intermediate compound for use in production of said dihalopropene compound SUMITOMO CHEMICAL CO (JP) 1998-07-15 EP disclosed
US-5698702-A INTERMEDIATES FOR INSECTICIDES, ACARICIDES SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1997-12-16 US disclosed
US-5530015-A Dihaloprene compound, insecticide/acaricide containing said dihalopropene compound as active ingredient, and intermediate compound for use in production of said dihalopropene compound SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1996-06-25 US disclosed
EP-0648729-A1 Dihalopropene compound, insecticide/acaricide containing said dihalopropene compound as active ingredient and intermediate compound for use in production of said dihalopropene compound SUMITOMO CHEMICAL COMPANY LIMITED (JP) 1995-04-19 EP disclosed