SCHEMBL8633895

SCHEMBL8633895

FC(F)(F)c1cc(Oc2cccc(Cl)c2)ccc1OCC=C(Cl)Cl

nearest known ligand 0.51

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
AR P10275 3/20 0.51
EPAS1 Q99814 1/20 0.44
MRGPRX4 Q96LA9 5/20 0.41
PPARG P37231 3/20 0.39
PPARD Q03181 3/20 0.39
FFAR1 O14842 1/20 0.39
MAOB P27338 1/20 0.39
AOC3 Q16853 1/20 0.39
MAPK10 P53779 1/20 0.39
P2RX4 Q99571 2/20 0.38
HTR2A P28223 1/20 0.37
SLC6A4 P31645 1/20 0.37
KCNH2 Q12809 1/20 0.37
PTGDR2 Q9Y5Y4 1/20 0.35
PPARA Q07869 1/20 0.35
WDR5 P61964 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8635779 0.90 AR (0.39) AREPAS1MRGPRX4PPARDMAOB
SCHEMBL8637041 0.89 AR (0.50) AREPAS1MRGPRX4PPARGPPARD
SCHEMBL8638861 0.89 AR (0.38) ARMRGPRX4PPARGPPARDMAOB
SCHEMBL8634174 0.89 AR (0.39) ARMRGPRX4PPARGPPARDMAOB
SCHEMBL8633081 0.88 MAOB (0.43) AREPAS1MRGPRX4MAOBAOC3
SCHEMBL8633011 0.87 MAPT (0.43) ARMAOBMAPK10
SCHEMBL8632777 0.86 FFAR4 (0.40) ARMRGPRX4FFAR1
SCHEMBL8636591 0.86 MAPK1 (0.43) AR
SCHEMBL8638742 0.85 FFAR1 (0.37) AREPAS1PPARGPPARDFFAR1
SCHEMBL8631990 0.84 PARG (0.41) ARMRGPRX4MAOBMAPK10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0648729-B1 Dihalopropene compound, insecticide/acaricide containing said dihalopropene compound as active ingredient and intermediate compound for use in production of said dihalopropene compound SUMITOMO CHEMICAL CO (JP) 1998-07-15 EP disclosed
US-5698702-A INTERMEDIATES FOR INSECTICIDES, ACARICIDES SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1997-12-16 US disclosed
US-5530015-A Dihaloprene compound, insecticide/acaricide containing said dihalopropene compound as active ingredient, and intermediate compound for use in production of said dihalopropene compound SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1996-06-25 US disclosed
EP-0648729-A1 Dihalopropene compound, insecticide/acaricide containing said dihalopropene compound as active ingredient and intermediate compound for use in production of said dihalopropene compound SUMITOMO CHEMICAL COMPANY LIMITED (JP) 1995-04-19 EP disclosed