SCHEMBL8634174

SCHEMBL8634174

FC(F)(F)c1cc(Oc2ccc(Oc3ccccc3)cc2)ccc1OCC=C(Cl)Cl

nearest known ligand 0.39

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
AR P10275 6/20 0.39
MAOB P27338 1/20 0.37
AOC3 Q16853 1/20 0.37
NR1H2 P55055 2/20 0.37
NR1H3 Q13133 2/20 0.37
PPARG P37231 2/20 0.36
ALOX5 P09917 1/20 0.36
PSEN1 P49768 1/20 0.36
PPARD Q03181 1/20 0.36
PPARA Q07869 1/20 0.36
FFAR4 Q5NUL3 2/20 0.36
STK39 Q9UEW8 1/20 0.36
PDK2 Q15119 1/20 0.36
MRGPRX4 Q96LA9 1/20 0.36
MGLL Q99685 1/20 0.35
HDAC1 Q13547 1/20 0.35
HDAC2 Q92769 1/20 0.35
PTGDR2 Q9Y5Y4 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8638861 0.97 AR (0.38) ARMAOBAOC3NR1H2NR1H3
SCHEMBL8636008 0.94 AR (0.38) ARNR1H2NR1H3PPARDFFAR4
SCHEMBL8632777 0.92 FFAR4 (0.40) ARNR1H2NR1H3FFAR4MRGPRX4
SCHEMBL8635779 0.91 AR (0.39) ARMAOBAOC3NR1H2NR1H3
SCHEMBL8631990 0.90 PARG (0.41) ARMAOBMRGPRX4
SCHEMBL8636474 0.90 RXRA (0.38) ARMAOBAOC3PPARGALOX5
SCHEMBL8633081 0.89 MAOB (0.43) ARMAOBAOC3MRGPRX4
SCHEMBL8633895 0.89 AR (0.51) ARMAOBAOC3PPARGPPARD
SCHEMBL8633864 0.89 MAOB (0.36) ARMAOBAOC3PPARGPPARD
SCHEMBL8636074 0.89 KDM4E (0.37) ARPPARA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0648729-B1 Dihalopropene compound, insecticide/acaricide containing said dihalopropene compound as active ingredient and intermediate compound for use in production of said dihalopropene compound SUMITOMO CHEMICAL CO (JP) 1998-07-15 EP disclosed
US-5698702-A INTERMEDIATES FOR INSECTICIDES, ACARICIDES SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1997-12-16 US disclosed
US-5530015-A Dihaloprene compound, insecticide/acaricide containing said dihalopropene compound as active ingredient, and intermediate compound for use in production of said dihalopropene compound SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1996-06-25 US disclosed
EP-0648729-A1 Dihalopropene compound, insecticide/acaricide containing said dihalopropene compound as active ingredient and intermediate compound for use in production of said dihalopropene compound SUMITOMO CHEMICAL COMPANY LIMITED (JP) 1995-04-19 EP disclosed