Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 2/20 | 0.36 |
| ▸ | MAOB | P27338 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | ESR1 | P03372 | 3/20 | 0.34 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.34 |
| ▸ | AR | P10275 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | UGT1A1 | P22309 | 1/20 | 0.33 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | DRD4 | P21917 | 1/20 | 0.32 |
| ▸ | DRD3 | P35462 | 1/20 | 0.32 |
| ▸ | WEE1 | P30291 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8641729 | 0.88 | MAOA (0.45) | ALDH1A1MAOAMAOBCYP3A4ESR1 | |
| SCHEMBL8980601 | 0.87 | APP (0.39) | ALDH1A1ESR1ESR2PBRM1KMT2A | |
| SCHEMBL8641437 | 0.87 | MAPT (0.40) | MAPTALDH1A1RAB9AMAOAMAOB | |
| SCHEMBL8368757 | 0.84 | KDM4E (0.35) | KDM4E | |
| SCHEMBL8980606 | 0.84 | FABP6 (0.41) | ALDH1A1RAB9AKDM4EKMT2ADRD2 | |
| SCHEMBL8573189 | 0.84 | MAOB (0.40) | MAPTALDH1A1MAOB | |
| SCHEMBL8640110 | 0.84 | ALDH1A1 (0.40) | MAPTALDH1A1RAB9ACYP3A4KDM4E | |
| SCHEMBL9174068 | 0.84 | MEN1 (0.43) | MAPTALDH1A1RAB9AKDM4EKMT2A | |
| SCHEMBL8980607 | 0.82 | PARP1 (0.39) | MAPTALDH1A1RAB9AKMT2A | |
| SCHEMBL7249895 | 0.81 | KDM4E (0.40) | MAPTALDH1A1RAB9AESR1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0566018-B1 | Benzoxazinone and benzothiazinone derivatives endowed with cardiovascular activity | ITALFARMACO SPA (IT) | 1998-08-05 | — | — | EP | disclosed |
| US-5480882-A | Benzoxazinone and benzothiazinone derivatives having cardiovascular activity | ITALFARMACO S.P.A. (IT) | 1996-01-02 | — | — | US | disclosed |
| EP-0566018-A2 | Benzoxazinone and benzothiazinone derivatives endowed with cardiovascular activity | ITALFARMACO S.p.A. (IT) | 1993-10-20 | — | — | EP | disclosed |