Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 7/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.35 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.34 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.34 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.34 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.34 |
| ▸ | CUL4A | Q13619 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8636633 | 0.87 | MAPT (0.41) | ALDH1A1PBRM1KMT2AESR1ESR2 | |
| SCHEMBL8368757 | 0.83 | KDM4E (0.35) | — | |
| SCHEMBL8640110 | 0.83 | ALDH1A1 (0.40) | APPALDH1A1MEN1KMT2A | |
| SCHEMBL8980606 | 0.83 | FABP6 (0.41) | CYP19A1ALDH1A1MEN1KMT2APRMT5 | |
| SCHEMBL8573189 | 0.83 | MAOB (0.40) | CYP19A1ALDH1A1 | |
| SCHEMBL9174068 | 0.83 | MEN1 (0.43) | CYP19A1ALDH1A1MEN1KMT2A | |
| SCHEMBL8980607 | 0.81 | PARP1 (0.39) | ALDH1A1KMT2A | |
| SCHEMBL7249895 | 0.80 | KDM4E (0.40) | ALDH1A1ESR1 | |
| SCHEMBL8575144 | 0.80 | MAPT (0.44) | CYP19A1ALDH1A1 | |
| SCHEMBL8654922 | 0.80 | CASP3 (0.40) | PRMT5WDR77 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0711286-A1 | BENZOXAZINONES AND BENZOTHIAZINONES ENDOWED WITH THERAPEUTIC ACTIVITY | ITALFARMACO S.p.A. (IT) | 1996-05-15 | — | — | EP | disclosed |
| WO-1995004048-A1 | BENZOXAZINONES AND BENZOTHIAZINONES ENDOWED WITH THERAPEUTIC ACTIVITY | ITALFARMACO S.P.A. (IT) | 1995-02-09 | — | — | WO | disclosed |