Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 2/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | HTR1E | P28566 | 2/20 | 0.40 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | DRD1 | P21728 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8637023 | 0.81 | ALOX5 (0.40) | ALOX5HDAC6HTR1ES1PR3CHRM3 | |
| SCHEMBL8639290 | 0.79 | CHRM3 (0.41) | ALOX5HDAC6CHRM3LMNACYP3A4 | |
| SCHEMBL69127 | 0.72 | HTR1E (0.65) | ALOX5HDAC6HTR1ES1PR3CHRM3 | |
| SCHEMBL28622389 | 0.72 | HTR1E (0.65) | ALOX5HDAC6HTR1ES1PR3CHRM3 | |
| SCHEMBL8960414 | 0.72 | CYP1A2 (0.46) | MEN1KMT2ACYP1A2TSHRCYP2C9 | |
| SCHEMBL8960400 | 0.72 | CYP1A2 (0.46) | MEN1KMT2ACYP1A2TSHRCYP2C9 | |
| SCHEMBL1177706 | 0.71 | HTR1E (0.60) | ALOX5HDAC6HTR1ES1PR3CHRM3 | |
| SCHEMBL1177709 | 0.71 | HTR1E (0.60) | ALOX5HDAC6HTR1ES1PR3CHRM3 | |
| SCHEMBL12531975 | 0.71 | HTR1E (0.63) | ALOX5HTR1ES1PR3CHRM3LMNA | |
| SCHEMBL67219 | 0.71 | HTR1E (0.63) | ALOX5HTR1ES1PR3CHRM3LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5776964-A | HYPOTENSIVE AGENTS; ANTICHOLESTEROL AGENTS; CARDIOVASCULAR DISORDERS | BAYER AKTIENGESELLSCHAFT (DE) | 1998-07-07 | — | — | US | disclosed |
| US-5521206-A | HYPOTENSIVE AGENTS, TREATMENT OF ATHEROSCLEROSIS | BAYER AKTIENGESELLSCHAFT (DE) | 1996-05-28 | — | — | US | disclosed |