Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM3 | P20309 | 2/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | DRD1 | P21728 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | FKBP1A | P62942 | 5/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8637023 | 0.94 | ALOX5 (0.40) | CHRM3ALOX5HDAC6CYP3A4CHRM2 | |
| SCHEMBL9010367 | 0.83 | FKBP1A (0.40) | CHRM3ALOX5HDAC6FKBP1A | |
| SCHEMBL8637017 | 0.79 | ALOX5 (0.41) | CHRM3ALOX5HDAC6CYP3A4CHRM2 | |
| SCHEMBL8636307 | 0.73 | CHRM3 (0.49) | CHRM3ALOX5HDAC6CYP3A4LMNA | |
| SCHEMBL8634916 | 0.70 | CHRM3 (0.47) | CHRM3ALOX5HDAC6LMNA | |
| SCHEMBL6912266 | 0.70 | CA1 (0.54) | LMNACYP1A2 | |
| SCHEMBL8637021 | 0.69 | HPGD (0.39) | CYP1A2THRB | |
| SCHEMBL7619544 | 0.69 | KMT2A (0.43) | LMNACYP1A2 | |
| SCHEMBL27483589 | 0.69 | CHRM3 (0.46) | CHRM3ALOX5HDAC6CYP3A4CHRM2 | |
| SCHEMBL27388408 | 0.69 | CHRM3 (0.46) | CHRM3ALOX5HDAC6CYP3A4CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5776964-A | HYPOTENSIVE AGENTS; ANTICHOLESTEROL AGENTS; CARDIOVASCULAR DISORDERS | BAYER AKTIENGESELLSCHAFT (DE) | 1998-07-07 | — | — | US | disclosed |
| US-5521206-A | HYPOTENSIVE AGENTS, TREATMENT OF ATHEROSCLEROSIS | BAYER AKTIENGESELLSCHAFT (DE) | 1996-05-28 | — | — | US | disclosed |