Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.61 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.61 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.61 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.57 |
| ▸ | ATM | Q13315 | 1/20 | 0.53 |
| ▸ | IGF1R | P08069 | 1/20 | 0.53 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | HTR1A | P08908 | 1/20 | 0.51 |
| ▸ | DRD2 | P14416 | 1/20 | 0.51 |
| ▸ | HTR7 | P34969 | 1/20 | 0.51 |
| ▸ | BACE1 | P56817 | 2/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.49 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.49 |
| ▸ | CA1 | P00915 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
| ▸ | CA7 | P43166 | 1/20 | 0.48 |
| ▸ | CA9 | Q16790 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8612798 | 0.91 | IGF1R (0.53) | MEN1KMT2AOPRM1OPRD1NPSR1 | |
| SCHEMBL24322660 | 0.87 | MEN1 (0.58) | MEN1KMT2AOPRM1OPRD1NPSR1 | |
| SCHEMBL8612921 | 0.87 | MEN1 (0.58) | MEN1KMT2AOPRM1OPRD1NPSR1 | |
| SCHEMBL8616272 | 0.81 | KMT2A (0.64) | MEN1KMT2AOPRM1OPRD1NPSR1 | |
| SCHEMBL9416485 | 0.80 | SLC6A3 (0.45) | MEN1KMT2AATMIGF1RDNM1 | |
| SCHEMBL5578085 | 0.79 | DPP7 (0.65) | MEN1KMT2AOPRM1OPRD1NPSR1 | |
| SCHEMBL10568220 | 0.78 | KMT2A (0.73) | MEN1KMT2AOPRM1OPRD1NPSR1 | |
| SCHEMBL7276991 | 0.78 | KMT2A (0.73) | MEN1KMT2AOPRM1OPRD1NPSR1 | |
| SCHEMBL7266954 | 0.77 | KMT2A (0.71) | MEN1KMT2AOPRM1OPRD1NPSR1 | |
| SCHEMBL10992721 | 0.76 | MEN1 (1.00) | MEN1KMT2AOPRM1OPRD1ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0549796-B1 | DIPHENYLPIPERAZINE DERIVATIVE AND DRUG FOR CIRCULATORY ORGAN CONTAINING THE SAME | POLA CHEM IND INC (JP) | 1998-04-29 | — | — | EP | disclosed |
| US-5391552-A | Has strong antagonism against calcium with less side effects | POLA CHEMICAL INDUSTRIES, INC. (JP) | 1995-02-21 | — | — | US | disclosed |
| EP-0612738-A1 | Diphenylpiperazine derivative and drug for circulatory organ containing the same | POLA CHEMICAL INDUSTRIES, INC. (JP) | 1994-08-31 | — | — | EP | disclosed |
| EP-0549796-A1 | DIPHENYLPIPERAZINE DERIVATIVE AND DRUG FOR CIRCULATORY ORGAN CONTAINING THE SAME | POLA CHEMICAL INDUSTRIES INC (JP) | 1993-07-07 | — | — | EP | disclosed |