Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | MCOLN2 | Q8IZK6 | 3/20 | 0.39 |
| ▸ | MCOLN3 | Q8TDD5 | 3/20 | 0.39 |
| ▸ | MCOLN1 | Q9GZU1 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CRACR2A | Q9BSW2 | 7/20 | 0.38 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.37 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8641061 | 0.99 | ALOX15 (0.39) | ALOX15MCOLN2MCOLN3MCOLN1ALDH1A1 | |
| SCHEMBL8639299 | 0.99 | ALOX15 (0.39) | ALOX15MCOLN2MCOLN3MCOLN1ALDH1A1 | |
| SCHEMBL8644075 | 0.85 | PTGS2 (0.35) | ALOX15MCOLN2MCOLN3MCOLN1CRACR2A | |
| SCHEMBL8641444 | 0.82 | CRACR2A (0.36) | CRACR2AFFAR4 | |
| SCHEMBL8637619 | 0.82 | ALOX15 (0.34) | ALOX15MCOLN2MCOLN3MCOLN1ALDH1A1 | |
| SCHEMBL8635861 | 0.81 | ALDH1A1 (0.37) | ALOX15MCOLN2MCOLN3MCOLN1ALDH1A1 | |
| SCHEMBL8688888 | 0.77 | ALDH1A1 (0.38) | MCOLN2MCOLN3MCOLN1ALDH1A1FFAR4 | |
| SCHEMBL8640765 | 0.76 | PTGS1 (0.51) | ALDH1A1FFAR4 | |
| SCHEMBL8641231 | 0.73 | PTGS2 (0.49) | ALDH1A1FFAR4 | |
| SCHEMBL8637763 | 0.72 | PTGS2 (0.40) | ALDH1A1FFAR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5756529-A | ANTIINFLAMMATORY | G.D. SEARLE & CO. (US) | 1998-05-26 | — | — | US | disclosed |
| US-5753688-A | ANTIINFLAMMATORY | TALLEY JOHN J (US) | 1998-05-19 | — | — | US | disclosed |
| US-5510496-A | ANTIINFLAMMATORY AGENTS | G.D. SEARLE & CO. (US) | 1996-04-23 | — | — | US | disclosed |
| US-5504215-A | Substituted pyrazolyl benzenesulfonamide compounds for the treatment of inflammation | G. D. SEARLE & CO. (US) | 1996-04-02 | — | — | US | disclosed |