Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 2/20 | 0.35 |
| ▸ | CRACR2A | Q9BSW2 | 6/20 | 0.33 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.33 |
| ▸ | ORAI1 | Q96D31 | 2/20 | 0.33 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | RBP4 | P02753 | 1/20 | 0.32 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.32 |
| ▸ | MCOLN2 | Q8IZK6 | 1/20 | 0.32 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.32 |
| ▸ | MCOLN1 | Q9GZU1 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8637271 | 0.85 | ALOX15 (0.40) | CRACR2AFFAR4ORAI1ALOX15MCOLN2 | |
| SCHEMBL8639299 | 0.84 | ALOX15 (0.39) | CRACR2AFFAR4ORAI1ALOX15MCOLN2 | |
| SCHEMBL8641061 | 0.84 | ALOX15 (0.39) | CRACR2AFFAR4ORAI1ALOX15MCOLN2 | |
| SCHEMBL8641444 | 0.82 | CRACR2A (0.36) | PTGS2CRACR2AFFAR4S1PR1 | |
| SCHEMBL8637619 | 0.80 | ALOX15 (0.34) | PTGS2CRACR2AFFAR4ORAI1ALOX15 | |
| SCHEMBL8644078 | 0.74 | PTGS2 (0.39) | PTGS2CRACR2AORAI1 | |
| SCHEMBL8688888 | 0.72 | ALDH1A1 (0.38) | PTGS2FFAR4S1PR1MCOLN2MCOLN3 | |
| SCHEMBL8640765 | 0.71 | PTGS1 (0.51) | PTGS2FFAR4 | |
| SCHEMBL6344531 | 0.70 | PTGS2 (0.54) | PTGS2ALOX15 | |
| SCHEMBL27967579 | 0.69 | PDPK1 (0.45) | PTGS2FFAR4ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5760068-A | NONSTEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G.D. SEARLE & CO. (US) | 1998-06-02 | — | — | US | disclosed |
| US-5756529-A | ANTIINFLAMMATORY | G.D. SEARLE & CO. (US) | 1998-05-26 | — | — | US | disclosed |
| US-5753688-A | ANTIINFLAMMATORY | TALLEY JOHN J (US) | 1998-05-19 | — | — | US | disclosed |
| US-5510496-A | ANTIINFLAMMATORY AGENTS | G.D. SEARLE & CO. (US) | 1996-04-23 | — | — | US | disclosed |
| US-5504215-A | Substituted pyrazolyl benzenesulfonamide compounds for the treatment of inflammation | G. D. SEARLE & CO. (US) | 1996-04-02 | — | — | US | disclosed |