Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 9/20 | 0.55 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.39 |
| ▸ | HRH2 | P25021 | 1/20 | 0.38 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.37 |
| ▸ | SLC1A3 | P43003 | 2/20 | 0.37 |
| ▸ | SLC1A2 | P43004 | 2/20 | 0.37 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8639357 | 0.84 | LTA4H (0.52) | LTA4H | |
| SCHEMBL8640498 | 0.81 | LTA4H (0.55) | LTA4HPTGS1PTGS2SLC1A3SLC1A2 | |
| SCHEMBL8638399 | 0.80 | LTA4H (0.55) | LTA4HPTGS1PTGS2TRPM8ALDH1A1 | |
| SCHEMBL3494088 | 0.74 | LTA4H (0.72) | LTA4H | |
| SCHEMBL3494092 | 0.73 | LTA4H (0.68) | LTA4HPTGS1PTGS2 | |
| SCHEMBL8909853 | 0.71 | LTA4H (0.42) | LTA4HPTGS1PTGS2TRPM8SIRT5 | |
| SCHEMBL2107118 | 0.71 | LTA4H (1.00) | LTA4H | |
| SCHEMBL3494091 | 0.70 | LTA4H (1.00) | LTA4H | |
| SCHEMBL22775084 | 0.69 | SLC1A3 (0.42) | HRH2HRH1SIRT5SLC1A3SLC1A2 | |
| SCHEMBL12347989 | 0.69 | HTT (0.38) | LTA4HHRH2HRH1SIRT5ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5700816-A | ANTIARTHRITIC AGENTS | G.D. SEARLE & CO. | 1997-12-23 | — | — | US | claimed |
| US-5723492-A | LTA4 hydrolase inhibitor pharmaceutical compositions and methods of use | G.D. SEARLE & CO. (US) | 1998-03-03 | — | — | US | disclosed |
| US-5719306-A | ANTIINFLAMMATORY AGENTS | G.D. SEARLE & CO. (US) | 1998-02-17 | — | — | US | disclosed |