Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 10/20 | 0.55 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.44 |
| ▸ | SLC1A3 | P43003 | 2/20 | 0.43 |
| ▸ | SLC1A2 | P43004 | 2/20 | 0.43 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.43 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.39 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.39 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | PTGES | O14684 | 1/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | RARB | P10826 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8644115 | 0.86 | LTA4H (0.51) | LTA4H | |
| SCHEMBL8637368 | 0.81 | LTA4H (0.55) | LTA4HPTGS1PTGS2SLC1A3SLC1A2 | |
| SCHEMBL8641130 | 0.81 | LTA4H (0.56) | LTA4HPTGS1PTGS2SLC1A3SLC1A2 | |
| SCHEMBL3494088 | 0.76 | LTA4H (0.72) | LTA4H | |
| SCHEMBL8642303 | 0.75 | PPARG (0.52) | LTA4HMAPK1ALOX5PPARA | |
| SCHEMBL8907826 | 0.74 | LTA4H (0.51) | LTA4HMAPK1RARBPPARA | |
| SCHEMBL3494092 | 0.73 | LTA4H (0.68) | LTA4HPTGS1PTGS2 | |
| SCHEMBL8907594 | 0.72 | LTA4H (0.51) | LTA4HPTGESALOX5RARBPPARA | |
| SCHEMBL2107118 | 0.71 | LTA4H (1.00) | LTA4H | |
| Bromide SCHEMBL6049769 | 0.69 | LTA4H (0.56) | LTA4HSLC1A3SLC1A2SLC1A1ITGB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5700816-A | ANTIARTHRITIC AGENTS | G.D. SEARLE & CO. | 1997-12-23 | — | — | US | claimed |
| US-5723492-A | LTA4 hydrolase inhibitor pharmaceutical compositions and methods of use | G.D. SEARLE & CO. (US) | 1998-03-03 | — | — | US | disclosed |
| US-5719306-A | ANTIINFLAMMATORY AGENTS | G.D. SEARLE & CO. (US) | 1998-02-17 | — | — | US | disclosed |