Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 1/20 | 0.36 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | AMY1A | P0DUB6 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | GSK3A | P49840 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.33 |
| ▸ | CCR4 | P51679 | 3/20 | 0.33 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | NT5E | P21589 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8638670 | 0.77 | HRH3 (0.38) | HRH3MAPTNT5EPOLBLMNA | |
| SCHEMBL8828092 | 0.74 | MMP1 (0.36) | HRH4GSK3AGSK3BDYRK1ACLK4 | |
| SCHEMBL19240443 | 0.73 | NQO2 (0.40) | HRH4AMY1AMAPTKDM4EPOLB | |
| SCHEMBL31214365 | 0.72 | MEN1 (0.34) | PTGESHRH4AMY1AMAPTCCR4 | |
| SCHEMBL31353552 | 0.72 | CYP1A2 (0.38) | MAPTPOLBLMNA | |
| SCHEMBL8828099 | 0.72 | KMT2A (0.32) | — | |
| SCHEMBL7970287 | 0.71 | AMY1A (0.46) | HRH4AMY1AMAPTCCR4NR1I3 | |
| SCHEMBL25343459 | 0.71 | TDP1 (0.44) | HRH4AMY1AMAPTCCR4POLB | |
| SCHEMBL30519502 | 0.71 | TDP1 (0.44) | HRH4AMY1AMAPTCCR4POLB | |
| SCHEMBL5036306 | 0.69 | MAPT (0.50) | AMY1AMAPTGSK3BKDM4EPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0640612-B1 | Novel derivatives from 2-(1H)-quinolinone, process for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 1998-04-22 | — | — | EP | disclosed |
| US-5646132-A | TREATING CEREBRAL ISCHEMIA | ADIR ET COMPAGNIE (FR) | 1997-07-08 | — | — | US | disclosed |
| US-5536709-A | INHIBITORS OF HYPERACTIVATION OF EXCITATORY AMINO ACIDS | ADIR ET COMPAGNIE (FR) | 1996-07-16 | — | — | US | disclosed |
| EP-0640612-A1 | Novel derivatives from 2-(1H)-quinolinone, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1995-03-01 | — | — | EP | disclosed |