Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PREP | P48147 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | APEX1 | P27695 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | METAP2 | P50579 | 1/20 | 0.44 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.44 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.44 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.44 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | NSD2 | O96028 | 2/20 | 0.41 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8633138 | 0.84 | PREP (0.53) | PREPKMT2AAPEX1GAAHPGD | |
| SCHEMBL8635557 | 0.80 | PREP (0.69) | PREPKMT2AAPEX1GAAHPGD | |
| SCHEMBL7319764 | 0.80 | GAA (0.47) | KMT2AGAAHPGDLMNAL3MBTL1 | |
| SCHEMBL8638521 | 0.79 | GAA (0.44) | PREPGAAALDH1A1 | |
| SCHEMBL7321743 | 0.74 | F2 (0.50) | HPGDHSD17B10ALDH1A1USP2 | |
| SCHEMBL31680569 | 0.73 | KMT2A (0.89) | KMT2AAPEX1GAAHPGDLMNA | |
| SCHEMBL11901003 | 0.73 | KMT2A (0.89) | KMT2AAPEX1GAAHPGDLMNA | |
| SCHEMBL10582691 | 0.73 | F2 (0.47) | KMT2AL3MBTL1ALDH1A1KDM4E | |
| SCHEMBL10585933 | 0.71 | L3MBTL1 (0.49) | HPGDL3MBTL1ALDH1A1 | |
| SCHEMBL8635576 | 0.71 | ITGB1 (0.43) | PREPLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5847155-A | Aromatic pyrrolidine amide prolyl endopeptidase inhibitors | PFIZER INC (US) | 1998-12-08 | — | — | US | disclosed |
| WO-1991018891-A1 | AROMATIC PYRROLIDINE AND THIAZOLIDINE AMIDES | PFIZER INC. (US) | 1991-12-12 | — | — | WO | disclosed |