SCHEMBL8637983

SCHEMBL8637983

COc1cc(/C=C/C(=O)Cl)cc(OC)c1OC

nearest known ligand 0.72

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.72
KDM4E B2RXH2 2/20 0.72
HTR1A P08908 2/20 0.72
HPGD P15428 2/20 0.72
GAA P10253 1/20 0.72
HTT P42858 1/20 0.72
HTR2C P28335 1/20 0.72
HSD17B10 Q99714 1/20 0.72
ABCB1 P08183 1/20 0.60
KRAS P01116 5/20 0.59
CA1 P00915 3/20 0.59
CA2 P00918 3/20 0.59
PSMB11 A5LHX3 1/20 0.59
PSMA7 O14818 1/20 0.59
PSMB1 P20618 1/20 0.59
PSMA1 P25786 1/20 0.59
PSMA2 P25787 1/20 0.59
PSMA3 P25788 1/20 0.59
PSMA4 P25789 1/20 0.59
PSMB8 P28062 1/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8637989 1.00 ALDH1A1 (0.72) ALDH1A1KDM4EHTR1AHPGDGAA
SCHEMBL4640353 0.88 ABCB1 (0.63) ALDH1A1KDM4EHTR1AHPGDGAA
SCHEMBL5570622 0.88 ABCB1 (0.63) ALDH1A1KDM4EHTR1AHPGDGAA
SCHEMBL7997556 0.87 TUBB4A (0.62) ALDH1A1KDM4EHTR1AHPGDGAA
SCHEMBL7997553 0.87 TUBB4A (0.62) ALDH1A1KDM4EHTR1AHPGDGAA
SCHEMBL29966256 0.86 CYP1A2 (0.74) ALDH1A1KDM4EHTR1AHPGDGAA
SCHEMBL2743907 0.85 ALDH1A1 (0.77) ALDH1A1KDM4EHTR1AHPGDGAA
SCHEMBL2743909 0.85 ALDH1A1 (0.77) ALDH1A1KDM4EHTR1AHPGDGAA
SCHEMBL17529421 0.85 TUBB4A (0.59) ALDH1A1KDM4EHTR1AHPGDGAA
Sinapic Acid Methyl Ether SCHEMBL207442 0.84 KDM4E (1.00) ALDH1A1KDM4EHTR1AHPGDGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 68 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-112028856-B Preparation method of cinepazide maleate intermediate 康普药业股份有限公司 2024-03-26 CN claimed
CN-112028856-A Preparation method of cinepazide maleate intermediate 康普药业股份有限公司 2020-12-04 CN claimed
CN-109115900-A The method of LC-MS/MS method measurement (E) 3,4,5- trimethoxy cinnamoyl chloride 中南粮油食品科学研究院有限公司 2019-01-01 CN claimed
CN-103239453-A Maleic acid cinepazide composition LIAONING YILING KECHUANG BIOLOG MEDICAL TECHNOLOGY CO LTD 2013-08-14 CN claimed
EP-0450892-A1 Cinnamic acid derivative and external skin treatment preparation containing the same SHISEIDO COMPANY LIMITED (JP) 1991-10-09 EP claimed
CN-117229205-B Preparation method and pharmaceutical application of phenyl acrylamide RHbDD1 inhibitor 中国医学科学院基础医学研究所 2025-03-21 CN disclosed
CN-112028856-B Preparation method of cinepazide maleate intermediate 康普药业股份有限公司 2024-03-26 CN disclosed
CN-112028856-B Preparation method of cinepazide maleate intermediate 康普药业股份有限公司 2024-03-26 CN disclosed
CN-117229205-A Preparation method and pharmaceutical application of phenyl acrylamide RHbDD1 inhibitor 中国医学科学院基础医学研究所 2023-12-15 CN disclosed
CN-116023247-A 2-propylene-1 ketone compound and preparation method and application thereof 暨南大学 2023-04-28 CN disclosed
US-20210206725-A1 PIPERLONGUMINE ANALOGUES AND USES THEREOF BIOVENTURES, LLC 2021-07-08 US disclosed
CN-112028856-A Preparation method of cinepazide maleate intermediate 康普药业股份有限公司 2020-12-04 CN disclosed
US-4450109-A VASODILATION; CARDIOTONIC AGENTS; HYPOTENSIVE AGENTS SS PHARMACEUTICAL CO., LTD. (JP) 1984-05-22 US disclosed
EP-0083712-A1 1-(3,4,5-Trimethoxycinnamoyl)-4-aminocarbonylethyl-substituted piperazine derivatives and a process for the preparation thereof Hokuriku Pharmaceutical Co.,Ltd (JP) 1983-07-20 EP disclosed
US-4369309-A HYPOTENSIVE AGENTS; UASODILATION; CARDIOVASCULAR DISORDERS SS PHARMACEUTICAL CO., LTD. (JP) 1983-01-18 US disclosed
US-4001218-A BACTERICIDES BAYER AKTIENGESELLSCHAFT (DT) 1977-01-04 US disclosed
US-3987036-A ACYLATION, CORONARY VASODILATORS CASSELLA FARBWERKE MAINKUR AKTIENGESELLSCHAFT (DT) 1976-10-19 US disclosed
US-3982011-A ANTIBIOTICS, ANIMAL GROWTH PROMOTERS BAYER AKTIENGESELLSCHAFT (DT) 1976-09-21 US disclosed
US-3933826-A ANALGESICS, VASODILATORS, HYPOTENSIVES NIPPON CHEMIPHAR CO., LTD. (JA) 1976-01-20 US disclosed
US-3931153-A BACTERICIDE BAYER AKTIENGESELLSCHAFT (DT) 1976-01-06 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210206725-A1 PIPERLONGUMINE ANALOGUES AND USES THEREOF AGER, MCL1, TP53 ALDH1A1 839/4885KDM4E 642/4885HTR1A 4090/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.