Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHPS | P49366 | 2/20 | 0.39 |
| ▸ | EDNRA | P25101 | 17/20 | 0.38 |
| ▸ | EDNRB | P24530 | 16/20 | 0.38 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.32 |
| ▸ | MMP13 | P45452 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8631708 | 0.92 | DHPS (0.42) | DHPSEDNRAEDNRB | |
| SCHEMBL8635760 | 0.85 | DHPS (0.50) | DHPSEDNRAEDNRB | |
| SCHEMBL8635722 | 0.80 | DHPS (0.35) | DHPSEDNRAEDNRB | |
| SCHEMBL7848871 | 0.77 | DHPS (0.62) | DHPS | |
| SCHEMBL7848869 | 0.74 | DHPS (0.49) | DHPS | |
| SCHEMBL8637899 | 0.73 | DHPS (0.43) | DHPSEDNRAEDNRB | |
| SCHEMBL7850931 | 0.68 | DHPS (0.69) | DHPS | |
| SCHEMBL7850930 | 0.67 | DHPS (0.56) | DHPSEDNRAEDNRB | |
| SCHEMBL7596071 | 0.65 | EDNRA (0.52) | EDNRAEDNRB | |
| SCHEMBL8398843 | 0.63 | DHPS (0.41) | DHPSEDNRAEDNRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5837708-A | CARDIOVASCULAR DISORDERS OF HYPERTENSION, ISCHEMIA, ANGINA PECTORIS AND VASOSPASMS | HOFFMANN-LA ROCHE INC. (US) | 1998-11-17 | — | — | US | claimed |
| US-5837708-A | CARDIOVASCULAR DISORDERS OF HYPERTENSION, ISCHEMIA, ANGINA PECTORIS AND VASOSPASMS | HOFFMANN-LA ROCHE INC. (US) | 1998-11-17 | — | — | US | disclosed |