Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 1/20 | 0.67 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.67 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.65 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.65 |
| ▸ | ACHE | P22303 | 4/20 | 0.59 |
| ▸ | LTA4H | P09960 | 4/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.51 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8638263 | 0.86 | TMEM97 (0.65) | HTR1ASLC6A4TMEM97SIGMAR1LTA4H | |
| SCHEMBL8637770 | 0.86 | TMEM97 (0.65) | HTR1ASLC6A4TMEM97SIGMAR1LTA4H | |
| SCHEMBL7402782 | 0.86 | TMEM97 (0.76) | HTR1ASLC6A4TMEM97SIGMAR1ACHE | |
| SCHEMBL7404295 | 0.82 | TMEM97 (0.82) | HTR1ASLC6A4TMEM97SIGMAR1LTA4H | |
| SCHEMBL7248846 | 0.80 | TMEM97 (0.71) | TMEM97SIGMAR1LTA4HCARM1PRMT6 | |
| SCHEMBL8637801 | 0.80 | TMEM97 (0.56) | HTR1ASLC6A4TMEM97SIGMAR1LTA4H | |
| SCHEMBL5888854 | 0.80 | TMEM97 (1.00) | SLC6A4TMEM97SIGMAR1LTA4HCARM1 | |
| SCHEMBL8644124 | 0.80 | TMEM97 (0.70) | HTR1ASLC6A4TMEM97SIGMAR1LTA4H | |
| SCHEMBL8639262 | 0.80 | SIGMAR1 (0.70) | HTR1ASLC6A4TMEM97SIGMAR1LTA4H | |
| Bromide SCHEMBL7253600 | 0.79 | TMEM97 (0.69) | TMEM97SIGMAR1LTA4HCARM1PRMT6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5723492-A | LTA4 hydrolase inhibitor pharmaceutical compositions and methods of use | G.D. SEARLE & CO. (US) | 1998-03-03 | — | — | US | disclosed |
| US-5719306-A | ANTIINFLAMMATORY AGENTS | G.D. SEARLE & CO. (US) | 1998-02-17 | — | — | US | disclosed |