SCHEMBL8633461

SCHEMBL8633461

ClC(Cl)=CCOc1ccc(Oc2cccc(Cl)c2)cc1Br

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PPARG P37231 2/20 0.39
PPARD Q03181 2/20 0.39
FFAR1 O14842 1/20 0.39
MAOB P27338 1/20 0.39
AOC3 Q16853 1/20 0.39
SLC6A4 P31645 3/20 0.37
WDR5 P61964 1/20 0.37
LMNA P02545 2/20 0.36
SLC6A2 P23975 1/20 0.36
SLC6A3 Q01959 1/20 0.36
HTR2A P28223 1/20 0.36
KCNH2 Q12809 1/20 0.36
NPC1 O15118 1/20 0.36
MAPT P10636 2/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
RHEB Q15382 1/20 0.35
EGFR P00533 1/20 0.35
LCK P06239 1/20 0.35
MEN1 O00255 1/20 0.35
KMT2A Q03164 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8635839 0.90 PPARG (0.39) PPARGPPARDFFAR1MAOBAOC3
SCHEMBL8633981 0.90 EPAS1 (0.38) LMNANPC1MAPTSMN1; SMN2
SCHEMBL8634621 0.88 MAOB (0.37) MAOBLMNANPC1MAPTSMN1; SMN2
SCHEMBL8632579 0.88 NPC1 (0.38) MAOBSLC6A4LMNAHTR2AKCNH2
SCHEMBL8634454 0.87 PPARD (0.40) PPARGPPARDFFAR1MAOBAOC3
SCHEMBL8638567 0.84 SLC6A4 (0.38) PPARGPPARDFFAR1SLC6A4LMNA
SCHEMBL8632980 0.82 MAOB (0.37) MAOBAOC3SLC6A4WDR5LMNA
SCHEMBL8638487 0.81 THRB (0.40) PPARGPPARDFFAR1MAOBAOC3
SCHEMBL8635458 0.81 PPARG (0.39) PPARGPPARDFFAR1MAOBAOC3
SCHEMBL8633895 0.81 AR (0.51) PPARGPPARDFFAR1MAOBAOC3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0648729-B1 Dihalopropene compound, insecticide/acaricide containing said dihalopropene compound as active ingredient and intermediate compound for use in production of said dihalopropene compound SUMITOMO CHEMICAL CO (JP) 1998-07-15 EP disclosed
US-5698702-A INTERMEDIATES FOR INSECTICIDES, ACARICIDES SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1997-12-16 US disclosed
US-5530015-A Dihaloprene compound, insecticide/acaricide containing said dihalopropene compound as active ingredient, and intermediate compound for use in production of said dihalopropene compound SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1996-06-25 US disclosed
EP-0648729-A1 Dihalopropene compound, insecticide/acaricide containing said dihalopropene compound as active ingredient and intermediate compound for use in production of said dihalopropene compound SUMITOMO CHEMICAL COMPANY LIMITED (JP) 1995-04-19 EP disclosed