Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Oxaloacetate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LDHA | P00338 | 1/20 | 0.53 |
| ▸ | SRR | Q9GZT4 | 1/20 | 0.53 |
| ▸ | OR51E2 | Q9H255 | 3/20 | 0.47 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | SLC13A3 | Q8WWT9 | 1/20 | 0.47 |
| ▸ | FEN1 | P39748 | 6/20 | 0.40 |
| ▸ | ERCC5 | P28715 | 5/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HAO1 | Q9UJM8 | 3/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.35 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.35 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.33 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.33 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxaloacetate SCHEMBL8464 | 0.96 | — | — | |
| Oxaloacetate SCHEMBL898612 | 0.96 | LDHA (0.57) | LDHASRROR51E2EGLN1MAPK1 | |
| Oxaloacetate SCHEMBL4298763 | 0.96 | LDHA (0.57) | LDHASRROR51E2EGLN1MAPK1 | |
| Oxaloacetate SCHEMBL25210523 | 0.93 | — | — | |
| Oxaloacetate SCHEMBL20912993 | 0.93 | LDHA (0.53) | LDHASRROR51E2EGLN1MAPK1 | |
| Oxaloacetate SCHEMBL9994505 | 0.93 | LDHA (0.53) | LDHASRROR51E2EGLN1MAPK1 | |
| Oxaloacetate SCHEMBL6545256 | 0.93 | LDHA (0.53) | LDHASRROR51E2EGLN1MAPK1 | |
| Oxaloacetate SCHEMBL9782818 | 0.93 | LDHA (0.53) | LDHASRROR51E2EGLN1MAPK1 | |
| Oxaloacetate SCHEMBL11328361 | 0.93 | LDHA (0.53) | LDHASRROR51E2EGLN1MAPK1 | |
| Oxaloacetate SCHEMBL6545252 | 0.93 | LDHA (0.53) | LDHASRROR51E2EGLN1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0852490-A2 | EMULSION AND MICELLAR FORMULATIONS FOR THE DELIVERY OF BIOLOGICALLY ACTIVE SUBSTANCES TO CELLS | UNIVERSITY OF PITTSBURGH (US) | 1998-07-15 | — | — | EP | disclosed |
| WO-1997011682-A2 | EMULSION AND MICELLAR FORMULATIONS FOR THE DELIVERY OF BIOLOGICALLY ACTIVE SUBSTANCES TO CELLS | UNIVERSITY OF PITTSBURGH (US) | 1997-04-03 | — | — | WO | disclosed |