Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 19/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | CASP3 | P42574 | 1/20 | 0.42 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.42 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8641926 | 0.92 | LTA4H (0.44) | LTA4H | |
| SCHEMBL8641994 | 0.77 | FFAR1 (0.40) | LTA4HLMNAL3MBTL1 | |
| SCHEMBL122993 | 0.75 | LTA4H (0.53) | LTA4HCYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL14478223 | 0.75 | ARG1 (0.60) | CYP1A2MAPK1 | |
| SCHEMBL27469449 | 0.75 | ARG1 (0.60) | CYP1A2MAPK1 | |
| SCHEMBL8644119 | 0.74 | PPARG (0.47) | LTA4HLMNAL3MBTL1 | |
| Bromide SCHEMBL6049805 | 0.72 | LTA4H (0.53) | LTA4HL3MBTL1 | |
| SCHEMBL8635978 | 0.72 | LTA4H (0.43) | LTA4HLMNA | |
| Bromide SCHEMBL6049807 | 0.72 | LTA4H (0.53) | LTA4HL3MBTL1 | |
| SCHEMBL8639342 | 0.72 | ELANE (0.43) | LTA4HLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5723492-A | LTA4 hydrolase inhibitor pharmaceutical compositions and methods of use | G.D. SEARLE & CO. (US) | 1998-03-03 | — | — | US | disclosed |
| US-5719306-A | ANTIINFLAMMATORY AGENTS | G.D. SEARLE & CO. (US) | 1998-02-17 | — | — | US | disclosed |