Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 1/20 | 0.43 |
| ▸ | LTA4H | P09960 | 7/20 | 0.41 |
| ▸ | S1PR1 | P21453 | 3/20 | 0.39 |
| ▸ | S1PR3 | Q99500 | 3/20 | 0.39 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.39 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 4/20 | 0.39 |
| ▸ | PPARA | Q07869 | 4/20 | 0.39 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.39 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8641923 | 0.94 | ELANE (0.42) | ELANELTA4HS1PR1S1PR3S1PR4 | |
| SCHEMBL8639942 | 0.92 | S1PR1 (0.43) | ELANELTA4HS1PR1S1PR3S1PR4 | |
| SCHEMBL8640088 | 0.89 | ELANE (0.45) | ELANELTA4HS1PR1S1PR3OPRK1 | |
| SCHEMBL8640706 | 0.89 | ALDH1A1 (0.40) | ELANES1PR1S1PR3S1PR4S1PR5 | |
| SCHEMBL8640101 | 0.80 | PPARA (0.47) | LTA4HS1PR1S1PR3PPARGPPARA | |
| SCHEMBL27859835 | 0.75 | ALDH1A1 (0.50) | LMNACA12CA1CA2CA9 | |
| SCHEMBL27859704 | 0.75 | ALDH1A1 (0.50) | LMNACA12CA1CA2CA9 | |
| SCHEMBL8639571 | 0.72 | LTA4H (0.44) | LTA4HLMNA | |
| SCHEMBL20853850 | 0.71 | ELANE (0.54) | ELANELTA4HS1PR1S1PR3S1PR4 | |
| SCHEMBL20853984 | 0.71 | ELANE (0.54) | ELANELTA4HS1PR1S1PR3S1PR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5723492-A | LTA4 hydrolase inhibitor pharmaceutical compositions and methods of use | G.D. SEARLE & CO. (US) | 1998-03-03 | — | — | US | disclosed |
| US-5719306-A | ANTIINFLAMMATORY AGENTS | G.D. SEARLE & CO. (US) | 1998-02-17 | — | — | US | disclosed |