Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Lithium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR88 | Q9GZN0 | 1/20 | 0.39 |
| ▸ | MMP3 | P08254 | 4/20 | 0.38 |
| ▸ | MME | P08473 | 1/20 | 0.38 |
| ▸ | CTSB | P07858 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | ANPEP | P15144 | 1/20 | 0.35 |
| ▸ | MMP8 | P22894 | 1/20 | 0.35 |
| ▸ | MMP1 | P03956 | 1/20 | 0.35 |
| ▸ | MMP9 | P14780 | 1/20 | 0.35 |
| ▸ | FDFT1 | P37268 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lithium Ion SCHEMBL8642409 | 1.00 | GPR88 (0.39) | GPR88MMP3MMECTSBLMNA | |
| SCHEMBL8642379 | 0.92 | MME (0.44) | GPR88MMP3MMECTSBANPEP | |
| Lithium Ion SCHEMBL8642081 | 0.89 | CTSB (0.42) | GPR88MMP3MMECTSBMMP8 | |
| Lithium Ion SCHEMBL8642364 | 0.88 | NPC1 (0.41) | GPR88CTSBLMNAMMP1MMP9 | |
| Lithium Ion SCHEMBL8640033 | 0.88 | NPC1 (0.41) | GPR88CTSBLMNAMMP1MMP9 | |
| SCHEMBL8641280 | 0.86 | GPR88 (0.46) | GPR88MMEMMP9 | |
| Lithium Ion SCHEMBL8637659 | 0.83 | MMP2 (0.44) | MMP3CTSBMMP8MMP9 | |
| Lithium Ion SCHEMBL8641788 | 0.81 | CTSB (0.40) | GPR88MMP3CTSBMMP1MMP9 | |
| SCHEMBL8644979 | 0.81 | REN (0.42) | GPR88MMP3MMELMNA | |
| SCHEMBL8638062 | 0.81 | REN (0.42) | GPR88MMP3MMELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0766694-B1 | PEPTIDE DERIVATIVES WITH METALLOPEPTIDASE INHIBITORY ACTIVITY | ZAMBON SPA (IT) | 1998-08-05 | — | — | EP | disclosed |