Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 14/20 | 0.82 |
| ▸ | PTGS1 | P23219 | 6/20 | 0.82 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.67 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9003005 | 0.90 | PTGS2 (0.67) | PTGS2PTGS1CYP2C9 | |
| SCHEMBL5229949 | 0.90 | PTGS2 (1.00) | PTGS2PTGS1CYP2C9 | |
| Sc-58125 SCHEMBL214120 | 0.90 | PTGS2 (1.00) | PTGS2PTGS1CYP2C9 | |
| Sc-58125 SCHEMBL12375146 | 0.90 | PTGS2 (1.00) | PTGS2PTGS1CYP2C9 | |
| SCHEMBL9002935 | 0.89 | PTGS2 (0.82) | PTGS2PTGS1CYP2C9 | |
| SCHEMBL9003167 | 0.89 | PTGS2 (0.65) | PTGS2PTGS1CYP2C9 | |
| SCHEMBL9260744 | 0.89 | PTGS2 (0.81) | PTGS2PTGS1CYP2C9 | |
| SCHEMBL9003046 | 0.88 | PTGS2 (0.82) | PTGS2PTGS1CYP2C9AOC3 | |
| SCHEMBL9002595 | 0.86 | PTGS2 (0.78) | PTGS2PTGS1CYP2C9AOC3 | |
| SCHEMBL8953925 | 0.86 | PTGS2 (0.78) | PTGS2PTGS1CYP2C9AOC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0731793-A1 | 1,5-DIPHENYL PYRAZOLE COMPOUNDS FOR TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-09-18 | — | — | EP | claimed |
| WO-1995015315-A1 | 1,5-DIPHENYL PYRAZOLE COMPOUNDS FOR TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1995-06-08 | — | — | WO | claimed |
| EP-0830133-A1 | THERAPEUTIC COMPOSITION FOR ARTHRITIS | Takeda Chemical Industries, Ltd. (JP) | 1998-03-25 | — | — | EP | disclosed |
| WO-1996033717-A1 | THERAPEUTIC COMPOSITION FOR ARTHRITIS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-10-31 | — | — | WO | disclosed |
| EP-0731793-A1 | 1,5-DIPHENYL PYRAZOLE COMPOUNDS FOR TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-09-18 | — | — | EP | disclosed |
| US-5475018-A | Antiinflammatory agent, antiarthritic agent; analgesics and antipyretics | G. D. SEARLE & CO. (US) | 1995-12-12 | — | — | US | disclosed |
| WO-1995015315-A1 | 1,5-DIPHENYL PYRAZOLE COMPOUNDS FOR TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1995-06-08 | — | — | WO | disclosed |