Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.37 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
| ▸ | CASR | P41180 | 2/20 | 0.34 |
| ▸ | CALM1 | P0DP23 | 2/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.33 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8639144 | 0.91 | ALDH1A1 (0.42) | MAPTIDO1HPGDCRHR1NR3C1 | |
| SCHEMBL8641462 | 0.89 | LTA4H (0.44) | MAPTHPGDKMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL8641228 | 0.89 | HPGD (0.38) | MAPTIDO1HPGDCRHR1NR3C1 | |
| SCHEMBL8641031 | 0.84 | NR3C1 (0.40) | MAPTIDO1HPGDCRHR1NR3C1 | |
| SCHEMBL8641291 | 0.81 | ALDH1A1 (0.39) | MAPTIDO1HPGDNR3C1KMT2A | |
| SCHEMBL8637517 | 0.80 | ALDH1A1 (0.42) | MAPTIDO1HPGDCRHR1NR3C1 | |
| SCHEMBL8639548 | 0.76 | NR3C1 (0.40) | MAPTIDO1HPGDNR3C1KMT2A | |
| SCHEMBL8641236 | 0.72 | NR3C1 (0.37) | MAPTIDO1NR3C1KMT2AALDH1A1 | |
| SCHEMBL16905119 | 0.72 | KCNJ11 (0.40) | MAPTCRHR1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL18589794 | 0.71 | HSD11B1 (0.42) | MAPTCRHR1NR3C1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0516257-B1 | Phenylbenzo[b]furans and -thiophenes, procedures for their preparation, and pharmaceutical compositions containing the same | SCHERING AG (DE) | 1998-08-05 | — | — | EP | disclosed |
| US-5470854-A | Antiestrogens | SCHERING AKTIENGESELLSCHAFT (DE) | 1995-11-28 | — | — | US | disclosed |
| WO-1992021669-A1 | 2-PHENYLBENZO[B]FURANS AND THIOPHENES, METHODS OF PREPARING THEM AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM | SCHERING AKTIENGESELLSCHAFT (DE) | 1992-12-10 | — | — | WO | disclosed |
| EP-0516257-A1 | Phenylbenzo[b]furans and -thiophenes, procedures for their preparation, and pharmaceutical compositions containing the same | SCHERING AKTIENGESELLSCHAFT (DE) | 1992-12-02 | — | — | EP | disclosed |