SCHEMBL8640563

SCHEMBL8640563

FC(F)(F)Oc1cc[c]c(-c2ccc3ccccc3c2)c1

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KAT6A Q92794 2/20 0.35
CYP1A2 P05177 2/20 0.35
CYP2A6 P11509 1/20 0.35
GSTP1 P09211 1/20 0.35
ESR1 P03372 1/20 0.35
ESR2 Q92731 1/20 0.35
GPR3 P46089 2/20 0.35
KIF11 P52732 1/20 0.35
SMN1; SMN2 Q16637 2/20 0.34
ALOX5 P09917 1/20 0.34
PTPN1 P18031 1/20 0.34
CYP11B1 P15538 1/20 0.33
CYP11B2 P19099 1/20 0.33
ACP1 P24666 1/20 0.33
HSD17B1 P14061 1/20 0.33
HSD17B2 P37059 1/20 0.33
GRM4 Q14833 1/20 0.33
PIM1 P11309 1/20 0.33
PIM2 Q9P1W9 1/20 0.33
SLC6A2 P23975 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8125229 0.84 METAP2 (0.38) GPR3KIF11ACP1IGF2BP2
SCHEMBL7685104 0.80 GPR3 (0.39) ESR2GPR3PTPN1HSD17B1HSD17B2
SCHEMBL7687621 0.80 GPR3 (0.44) GPR3KIF11SMN1; SMN2FFAR1FFAR4
SCHEMBL8089523 0.80 CYP1A2 (0.53) CYP1A2CYP2A6GSTP1ESR1ESR2
SCHEMBL6987825 0.79 CYP1A2 (0.50) CYP1A2CYP2A6GSTP1ESR1ESR2
SCHEMBL8128913 0.78 DHODH (0.39) GPR3ALOX5ALDH1A1MAPTFFAR1
SCHEMBL8634666 0.78 ESR1 (0.37) KAT6ACYP1A2CYP2A6GSTP1ESR1
SCHEMBL5320552 0.77 PTPN5 (0.39) SLC6A4ALDH1A1
SCHEMBL2448879 0.77 ESR1 (0.48) CYP1A2GSTP1ESR1ESR2SMN1; SMN2
SCHEMBL10448716 0.76 CYP2A6 (0.50) CYP1A2CYP2A6GSTP1ESR1ESR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0853764-A1 COMBINATORIAL SYNTHESIS AND HIGH-THROUGHPUT SCREENING OF A REV-INHIBITING ARYLIDENEDIAMIDE ARRAY ARQULE, INC. (US) 1998-07-22 EP claimed
WO-1996035953-A1 COMBINATORIAL SYNTHESIS AND HIGH-THROUGHPUT SCREENING OF A REV-INHIBITING ARYLIDENEDIAMIDE ARRAY ARQULE, INC. (US) 1996-11-14 WO claimed
EP-0853764-A1 COMBINATORIAL SYNTHESIS AND HIGH-THROUGHPUT SCREENING OF A REV-INHIBITING ARYLIDENEDIAMIDE ARRAY ARQULE, INC. (US) 1998-07-22 EP disclosed
WO-1996035953-A1 COMBINATORIAL SYNTHESIS AND HIGH-THROUGHPUT SCREENING OF A REV-INHIBITING ARYLIDENEDIAMIDE ARRAY ARQULE, INC. (US) 1996-11-14 WO disclosed